Archived Comments for:
Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling
I have two comments about this work:
1) In the last portion of the discussion section of this published work, the authors reported measuring the maximum tolerated (MTD) dose for Thymoquinone in RATS and i quote: "We found that the maximum tolerated dose was 20 mg/kg in male and 15 mg/kg in female rodent (mice or rats ?), whereas for oral administration it was 150 mg/kg in both male and female rats(?)". I wonder about the relavence between this measured MTD values and the actual work done by the authors where MICE are used as an experimental model. Is there a mistake by the authors (typographical mistake) in reporting the MTD for RATS which it should be for MICE ?
2) It seems that the authors (Badr et al, 2013) of the published article are not updated with the toxicity studies of Thymoquinone. Please refer to an article published in 2012; Indian Journal of Pharmaceutical Sciences regarding this matter.
Lipids in Health and Disease
Thymoquinone Toxicity
9 January 2015
I have two comments about this work:
1) In the last portion of the discussion section of this published work, the authors reported measuring the maximum tolerated (MTD) dose for Thymoquinone in RATS and i quote: "We found that the maximum tolerated dose was 20 mg/kg in male and 15 mg/kg in female rodent (mice or rats ?), whereas for oral administration it was 150 mg/kg in both male and female rats(?)". I wonder about the relavence between this measured MTD values and the actual work done by the authors where MICE are used as an experimental model. Is there a mistake by the authors (typographical mistake) in reporting the MTD for RATS which it should be for MICE ?
2) It seems that the authors (Badr et al, 2013) of the published article are not updated with the toxicity studies of Thymoquinone. Please refer to an article published in 2012; Indian Journal of Pharmaceutical Sciences regarding this matter.
Competing interests
There is NO competing of interests.