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Figure 5 | Lipids in Health and Disease

Figure 5

From: C-reactive protein/oxidised low-density lipoprotein/β2-glycoprotein I complex promotes atherosclerosis in diabetic BALB/c mice via p38mitogen-activated protein kinase signal pathway

Figure 5

Effect of CRP/oxLDL/β2GPI on receptors associated with lipid metabolism gene expression in the aortas. After induction of diabetes and treatment with oxLDL, β2GPI, oxLDL/β2GPI complex, CRP/oxLDL/β2GPI complex and PBS (as described in the Methods section), aortas were removed and the expression of selected genes was measured using real-time PCR. Estimates of the quantity of the PCR product were obtained by densitometry using the Quantity One analysis software package. Results are show as means ± SEM of mRNA level normalized to β-actin in the normal (non-diabetes) group. A: ABCA1 mRNA and ABCG1 mRNA expression level in the aortas. B: CD36 mRNA and SR-BI mRNA expression level in the aortas. Expression level of NC group was normalized as 1, n= 4. *P < 0.05, compared with the CRP/oxLDL/β2GPI group, †P < 0.05, compared with the PBS group, ‡P< 0.05, compared with the NC group.

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Lipids in Health and Disease

ISSN: 1476-511X