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Table 2 Effect of WP supplementation on the levels of free radicals in the wound tissues of diabetic mice

From: Camel whey protein enhances diabetic wound healing in a streptozotocin-induced diabetic mouse model: the critical role of β-Defensin-1, -2 and -3

  

Blood parameters

Wound tissue parameters

Day post injury

Groups

Glucose

Insulin

ROS

Hydroperoxide

  

(mg/dl)

(ng/ml)

(μmol/ml)

(mg/100ml)

Day 1

Control

137±13

5.1±0.48

41±5.1

23±2.2

Diabetic

411±37 *#

1.7±0.15 *#

92±8.4 *#

59.1±4.6 *#

Diabetic + WP

287±27 +

3.1±0.29 +

68±7.1 +

33.4±4.2 +

Day 4

Control

143±14.4

6.4±0.61

58±6.2

17±2.1

Diabetic

393±33 *#

1.4±0.3 *#

117±12 *#

67±5.3 *#

Diabetic + WP

279±28 +

2.9±0.25 +

79±8.1 +

37.6±4.1 +

Day 7

Control

111±13

5.7±0.5

49.8±5.1

27.1±2.9

Diabetic

376±33 *#

1.1±0.22 *#

132±14 *#

59.8±5.5 *#

Diabetic + WP

267±24.8 +

3.4±0.3 +

71.7±8 +

42.1±4.1 +

Day 10

Control

99±10.4

7.1±0.75

61.5±5.6

19.9±1.7

Diabetic

419±38.4 *#

1.6±0.19 *#

126±13 *#

48.6±4.9 *#

Diabetic + WP

284±26 +

3.9±0.38 +

83±7.5 +

34±3.8 +

Day 13

Control

119±13.4

6.4±0.6

52.3±4.8

15.5±1.1

Diabetic

373.6±32 *#

1.45±0.2 *#

89.9±7.8 *#

39.8±3.2 *#

Diabetic + WP

261±25.5 +

3.3±0.3 +

67.1±7.2 +

24.6±2.6 +

  1. The levels of blood glucose and insulin in the three groups of mice were monitored on days 1, 4, 7, 10 and 13 post wounding. The levels of ROS and hydroperoxide in the excisional wound tissue collected from the three groups of mice on days 1, 4, 7, 10 and 13 post wounding were also measured. The accumulated data from 10 individual mice from each group are shown. The data were first tested for normality and variance homogeneity prior to any further statistical analysis. The data were normally distributed and are expressed as the mean ± SEM. *P < 0.05, diabetic vs. control; +P < 0.05, diabetic + WP vs. control; #P < 0.05, diabetic + WP vs. diabetic (ANOVA with Tukey’s post-test).