Figure 5
From: PPARγ as a sensor of lipase activity and a target for the lipase inhibitor orlistat
hBD1 protein expression in HT29 cell supernatants and cell death following 24 h exposure to Orlistat, Rosiglitazone and DMSO control. Each datapoint represents mean ± SD (n=3). Significant differences between treatment and control are shown as *(p<0.05). The dashed line indicates the upper value of the error bar for the DMSO control sample. hBD1 protein in DMSO control cell supernatant (Δ), hBD1 protein in Rosiglitazone treated cell supernatant (○),hBD1 protein in Orlistat treated cell supernatant (□). Tissue culture percent cell death at 24 h; DMSO control cells (▲), cell death in Rosiglitazone treated cells (●), cell death in Orlistat treated cells (■).