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Table 3 Plasma PL fatty acid profile of GES1, MGC and SGC cells supplemented with various fatty acids (180 μM) and methotrexate for 48 hours

From: Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro

FA

Fatty Acid supplementation or Methotrexate supplementation

LA

ALA

AA

EPA

DHA

MTX

 

GES1 MGC SGC

GES1 MGC SGC

GES1 MGC SGC

GES1 MGC SGC

GES1 MGC SGC

GES1 MGC SGC

PA

↔ ↓ ↔

↔ ↔ ↔

↓ ↔ ↔

↓ ↔ ↔

↔ ↔ ↓

↔ ↓ ↔

SA

↑ ↓ ↔

↔ ↓ ↔

↓ ↑ ↑

↓ ↑ ↔

↓ ↑ ↔

↔ ↔ ↓

OA

↔ ↓ ↔

↔ ↓ ↔

↓ ↔ ↔

↓ ↔ ↓

↓ ↔ ↓

↑ ↓ ↔

LA

↔ ↑↑ ↓

↓ ↓ ↓

↑ ↔ ↔

↓ ↔ ↔

↔ ↔ ↔

↔ ↑ ↔

GLA

↓ ↑↑ ↔

↔ ↔ ↔

↑ ↓ ↔

↑↑ ↑ ↔

↓ ↔ ↔

↔ ↑↑ ↔

DGLA

↔ ↔ ↑

↔ ↔ ↑

↔ ↑ ↔

↓ ↑ ↔

↔ ↔ ↔

↓ ↑ ↔

AA

↔ ↓ ↑

↔ ↔ ↔

↑↑ ↔ ↔

↓ ↓ ↓

↔ ↔ ↔

↔ ↑ ↔

ALA

↓ ↔ ↓

↔ ↑↑ ↑

↑ ↔ ↔

↔ ↔ ↔

↔ ↔ ↔

↓ ↑ ↔

EPA

↔ ↓ ↑

↔ ↓ ↔

↑ ↔ ↔

↑↑ ↑ ↔

↓↓ ↔ ↔

↔ ↑ ↔

DHA

↔ ↔ ↔

↔ ↓ ↓

↑ ↓ ↓

↓ ↓ ↓

↑↑ ↔ ↑

↔ ↑↑ ↑

  1. ↔ = No change.
  2. ↑ = Increase.
  3. ↓ = Decrease.
  4. ↑↑ = Increase in the fatty acid concentration by more than 2–4 fold compared to control.
  5. ↓↓ = Decrease in the fatty acid concentration by more than 2–4 fold compared to control.