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Table 3 Plasma PL fatty acid profile of GES1, MGC and SGC cells supplemented with various fatty acids (180 μM) and methotrexate for 48 hours

From: Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro

FA Fatty Acid supplementation or Methotrexate supplementation
LA ALA AA EPA DHA MTX
  GES1 MGC SGC GES1 MGC SGC GES1 MGC SGC GES1 MGC SGC GES1 MGC SGC GES1 MGC SGC
PA ↔ ↓ ↔ ↔ ↔ ↔ ↓ ↔ ↔ ↓ ↔ ↔ ↔ ↔ ↓ ↔ ↓ ↔
SA ↑ ↓ ↔ ↔ ↓ ↔ ↓ ↑ ↑ ↓ ↑ ↔ ↓ ↑ ↔ ↔ ↔ ↓
OA ↔ ↓ ↔ ↔ ↓ ↔ ↓ ↔ ↔ ↓ ↔ ↓ ↓ ↔ ↓ ↑ ↓ ↔
LA ↔ ↑↑ ↓ ↓ ↓ ↓ ↑ ↔ ↔ ↓ ↔ ↔ ↔ ↔ ↔ ↔ ↑ ↔
GLA ↓ ↑↑ ↔ ↔ ↔ ↔ ↑ ↓ ↔ ↑↑ ↑ ↔ ↓ ↔ ↔ ↔ ↑↑ ↔
DGLA ↔ ↔ ↑ ↔ ↔ ↑ ↔ ↑ ↔ ↓ ↑ ↔ ↔ ↔ ↔ ↓ ↑ ↔
AA ↔ ↓ ↑ ↔ ↔ ↔ ↑↑ ↔ ↔ ↓ ↓ ↓ ↔ ↔ ↔ ↔ ↑ ↔
ALA ↓ ↔ ↓ ↔ ↑↑ ↑ ↑ ↔ ↔ ↔ ↔ ↔ ↔ ↔ ↔ ↓ ↑ ↔
EPA ↔ ↓ ↑ ↔ ↓ ↔ ↑ ↔ ↔ ↑↑ ↑ ↔ ↓↓ ↔ ↔ ↔ ↑ ↔
DHA ↔ ↔ ↔ ↔ ↓ ↓ ↑ ↓ ↓ ↓ ↓ ↓ ↑↑ ↔ ↑ ↔ ↑↑ ↑
  1. ↔ = No change.
  2. ↑ = Increase.
  3. ↓ = Decrease.
  4. ↑↑ = Increase in the fatty acid concentration by more than 2–4 fold compared to control.
  5. ↓↓ = Decrease in the fatty acid concentration by more than 2–4 fold compared to control.