From: Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern
 | Frequency (%) | TG | TC | HDL-C | LDL-C | ||||
---|---|---|---|---|---|---|---|---|---|
Median (Q1–Q3) | P | Median (Q1–Q3) | P | Median (Q1–Q3) | P | Median (Q1–Q3) | P | ||
Male (n = 584) | |||||||||
rs2301756 | |||||||||
GG | 439 (75.2) | 1.59 (1.09–2.37) | – | 5.02 (4.45–5.63) | – | 1.25 (1.10–1.43) | – | 3.10 (2.68–3.61) | – |
GA | 131 (22.4) | 1.63 (1.20–2.47) | 0.319 | 5.07 (4.52–5.84) | 0.161 | 1.30 (1.10–1.47) | 0.164 | 3.10 (2.68–3.74) | 0.236 |
AA | 14 (2.4) | 1.74 (1.19–2.85) | 0.516 | 5.03 (4.76–5.32) | 0.877 | 1.30 (1.12–1.60) | 0.572 | 2.98 (2.75–3.65) | 0.969 |
rs12423190 | |||||||||
TT | 304 (52.0) | 1.57 (1.08–2.44) | – | 4.99 (4.46–5.57) | – | 1.27 (1.10–1.47) | – | 3.10 (2.65–3.62) | – |
TC | 227 (38.9) | 1.67 (1.26–2.33) | 0.184 | 5.10 (4.49–5.74) | 0.411 | 1.26 (1.09–1.42) | 0.309 | 3.14 (2.70–3.63) | 0.380 |
CC | 53 (9.1) | 1.64 (1.08–2.68) | 0.120 | 5.07 (4.49–5.76) | 0.219 | 1.30 (1.07–1.51) | 0.203 | 3.00 (2.72–3.70) | 0.595 |
 rs12229892 | |||||||||
GG | 189 (32.4) | 1.67 (1.21–2.53) | – | 5.13 (4.53–5.72) | – | 1.30 (1.10–1.47) | – | 3.11 (2.70–3.67) | – |
GA | 285 (48.8) | 1.61 (1.20–2.45) | 0.405 | 5.02 (4.49–5.64) | 0.106 | 1.23 (1.10–1.41) | 0.988 | 3.14 (2.67–3.66) | 0.386 |
AA | 110 (18.8) | 1.41 (0.96–2.16) | 0.009 | 4.96 (4.35–5.50) | 0.118 | 1.29 (1.14–1.49) | 0.562 | 3.08 (2.64–3.57) | 0.354 |
rs7958372 | |||||||||
TT | 439 (75.2) | 1.59 (1.10–2.37) | – | 5.03 (4.46–5.64) | – | 1.25 (1.10–1.43) | – | 3.10 (2.69–3.61) | – |
TC | 135 (23.1) | 1.64 (1.20–2.47) | 0.351 | 5.05 (4.54–5.77) | 0.200 | 1.30 (1.10–1.47) | 0.197 | 3.10 (2.68–3.74) | 0.260 |
CC | 10 (1.7) | 1.89 (1.22–2.85) | 0.619 | 4.86 (4.56–5.28) | 0.648 | 1.30 (1.12–1.45) | 0.615 | 2.94 (2.61–3.65) | 0.535 |
rs4767860 | |||||||||
AA | 198 (33.9) | 1.53 (1.02–2.37) | – | 4.98 (4.42–5.51) | – | 1.25 (1.10–1.45) | – | 3.10 (2.60–3.60) | – |
GA | 282 (48.3) | 1.63 (1.20–2.41) | 0.024 | 5.03 (4.48–5.68) | 0.185 | 1.28 (1.09–1.43) | 0.973 | 3.10 (2.67–3.60) | 0.252 |
GG | 104 (17.8) | 1.64 (1.22–2.64) | 0.028 | 5.13 (4.56–5.80) | 0.021 | 1.30 (1.10–1.47) | 0.598 | 3.15 (2.75–3.71) | 0.084 |
Female (n = 419) | |||||||||
rs2301756 | |||||||||
GG | 311 (74.2) | 1.19 (0.83–1.71) | – | 4.94 (4.49–5.60) | – | 1.48 (1.27–1.69) | – | 2.98 (2.50–3.43) | – |
GA | 101 (24.1) | 1.25 (0.85–1.85) | 0.780 | 5.23 (4.72–5.87) | 0.071 | 1.51 (1.27–1.76) | 0.283 | 3.12 (2.66–3.69) | 0.083 |
AA | 7 (1.7) | 2.33 (1.14–3.20) | 0.005 | 5.02 (4.53–6.20) | 0.300 | 1.37 (1.21–1.59) | 0.605 | 3.16 (2.42–3.84) | 0.555 |
rs12423190 | |||||||||
TT | 211 (50.4) | 1.25 (0.82–1.75) | – | 5.03 (4.53–5.67) | – | 1.50 (1.27–1.71) | – | 3.04 (2.57–3.56) | – |
TC | 172 (41.0) | 1.18 (0.87–1.64) | 0.592 | 5.12 (4.47–5.68) | 0.709 | 1.46 (1.26–1.66) | 0.149 | 3.00 (2.47–3.56) | 0.759 |
CC | 36 (8.6) | 1.10 (0.80–1.99) | 0.388 | 5.00 (4.64–5.32) | 0.877 | 1.40 (1.22–1.74) | 0.184 | 2.97 (2.52–3.35) | 0.895 |
rs12229892 | |||||||||
GG | 153 (36.5) | 1.21 (0.85–1.71) | – | 5.11 (4.57–5.64) | – | 1.48 (1.26–1.70) | – | 3.00 (2.65–3.48) | – |
GA | 200 (47.7) | 1.23 (0.86–1.74) | 0.497 | 5.04 (4.45–5.67) | 0.599 | 1.45 (1.27–1.68) | 0.880 | 3.00 (2.51–3.60) | 0.873 |
AA | 66 (15.8) | 1.19 (0.80–1.68) | 0.232 | 5.07 (4.60–5.61) | 0.463 | 1.53 (1.30–1.77) | 0.128 | 3.07 (2.67–3.40) | 0.526 |
rs7958372 | |||||||||
TT | 312 (74.5) | 1.19 (0.83–1.71) | – | 4.95 (4.50–5.60) | – | 1.48 (1.27–1.69) | – | 2.98 (2.51–3.44) | – |
TC | 100 (23.9) | 1.25 (0.87–1.88) | 0.787 | 5.22 (4.67–5.93) | 0.090 | 1.52 (1.26–1.76) | 0.319 | 3.10 (2.62–3.63) | 0.278 |
CC | 7 (1.7) | 1.92 (0.85–2.33) | 0.201 | 5.02 (4.68–6.20) | 0.183 | 1.31 (1.21–1.59) | 0.418 | 3.48 (3.16–4.06) | 0.019 |
rs4767861 | |||||||||
AA | 137 (32.7) | 1.23 (0.81–1.68) | – | 4.94 (4.53–5.61) | – | 1.51 (1.30–1.70) | – | 3.00 (2.57–3.40) | – |
GA | 198 (47.3) | 1.21 (0.86–1.79) | 0.474 | 5.11 (4.45–5.64) | 0.515 | 1.45 (1.24–1.70) | 0.113 | 2.96 (2.46–3.54) | 0.600 |
GG | 84 (20.0) | 1.21 (0.84–1.91) | 0.134 | 5.16 (4.68–5.87) | 0.123 | 1.41 (1.26–1.67) | 0.236 | 3.13 (2.68–3.58) | 0.132 |