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Table 3 Associations between SNPs of PTNP11 and lipid levels stratified by gender

From: Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern

 

Frequency (%)

TG

TC

HDL-C

LDL-C

Median (Q1–Q3)

P

Median (Q1–Q3)

P

Median (Q1–Q3)

P

Median (Q1–Q3)

P

Male (n = 584)

rs2301756

GG

439 (75.2)

1.59 (1.09–2.37)

–

5.02 (4.45–5.63)

–

1.25 (1.10–1.43)

–

3.10 (2.68–3.61)

–

GA

131 (22.4)

1.63 (1.20–2.47)

0.319

5.07 (4.52–5.84)

0.161

1.30 (1.10–1.47)

0.164

3.10 (2.68–3.74)

0.236

AA

14 (2.4)

1.74 (1.19–2.85)

0.516

5.03 (4.76–5.32)

0.877

1.30 (1.12–1.60)

0.572

2.98 (2.75–3.65)

0.969

rs12423190

TT

304 (52.0)

1.57 (1.08–2.44)

–

4.99 (4.46–5.57)

–

1.27 (1.10–1.47)

–

3.10 (2.65–3.62)

–

TC

227 (38.9)

1.67 (1.26–2.33)

0.184

5.10 (4.49–5.74)

0.411

1.26 (1.09–1.42)

0.309

3.14 (2.70–3.63)

0.380

CC

53 (9.1)

1.64 (1.08–2.68)

0.120

5.07 (4.49–5.76)

0.219

1.30 (1.07–1.51)

0.203

3.00 (2.72–3.70)

0.595

 rs12229892

GG

189 (32.4)

1.67 (1.21–2.53)

–

5.13 (4.53–5.72)

–

1.30 (1.10–1.47)

–

3.11 (2.70–3.67)

–

GA

285 (48.8)

1.61 (1.20–2.45)

0.405

5.02 (4.49–5.64)

0.106

1.23 (1.10–1.41)

0.988

3.14 (2.67–3.66)

0.386

AA

110 (18.8)

1.41 (0.96–2.16)

0.009

4.96 (4.35–5.50)

0.118

1.29 (1.14–1.49)

0.562

3.08 (2.64–3.57)

0.354

rs7958372

TT

439 (75.2)

1.59 (1.10–2.37)

–

5.03 (4.46–5.64)

–

1.25 (1.10–1.43)

–

3.10 (2.69–3.61)

–

TC

135 (23.1)

1.64 (1.20–2.47)

0.351

5.05 (4.54–5.77)

0.200

1.30 (1.10–1.47)

0.197

3.10 (2.68–3.74)

0.260

CC

10 (1.7)

1.89 (1.22–2.85)

0.619

4.86 (4.56–5.28)

0.648

1.30 (1.12–1.45)

0.615

2.94 (2.61–3.65)

0.535

rs4767860

AA

198 (33.9)

1.53 (1.02–2.37)

–

4.98 (4.42–5.51)

–

1.25 (1.10–1.45)

–

3.10 (2.60–3.60)

–

GA

282 (48.3)

1.63 (1.20–2.41)

0.024

5.03 (4.48–5.68)

0.185

1.28 (1.09–1.43)

0.973

3.10 (2.67–3.60)

0.252

GG

104 (17.8)

1.64 (1.22–2.64)

0.028

5.13 (4.56–5.80)

0.021

1.30 (1.10–1.47)

0.598

3.15 (2.75–3.71)

0.084

Female (n = 419)

rs2301756

GG

311 (74.2)

1.19 (0.83–1.71)

–

4.94 (4.49–5.60)

–

1.48 (1.27–1.69)

–

2.98 (2.50–3.43)

–

GA

101 (24.1)

1.25 (0.85–1.85)

0.780

5.23 (4.72–5.87)

0.071

1.51 (1.27–1.76)

0.283

3.12 (2.66–3.69)

0.083

AA

7 (1.7)

2.33 (1.14–3.20)

0.005

5.02 (4.53–6.20)

0.300

1.37 (1.21–1.59)

0.605

3.16 (2.42–3.84)

0.555

rs12423190

TT

211 (50.4)

1.25 (0.82–1.75)

–

5.03 (4.53–5.67)

–

1.50 (1.27–1.71)

–

3.04 (2.57–3.56)

–

TC

172 (41.0)

1.18 (0.87–1.64)

0.592

5.12 (4.47–5.68)

0.709

1.46 (1.26–1.66)

0.149

3.00 (2.47–3.56)

0.759

CC

36 (8.6)

1.10 (0.80–1.99)

0.388

5.00 (4.64–5.32)

0.877

1.40 (1.22–1.74)

0.184

2.97 (2.52–3.35)

0.895

rs12229892

GG

153 (36.5)

1.21 (0.85–1.71)

–

5.11 (4.57–5.64)

–

1.48 (1.26–1.70)

–

3.00 (2.65–3.48)

–

GA

200 (47.7)

1.23 (0.86–1.74)

0.497

5.04 (4.45–5.67)

0.599

1.45 (1.27–1.68)

0.880

3.00 (2.51–3.60)

0.873

AA

66 (15.8)

1.19 (0.80–1.68)

0.232

5.07 (4.60–5.61)

0.463

1.53 (1.30–1.77)

0.128

3.07 (2.67–3.40)

0.526

rs7958372

TT

312 (74.5)

1.19 (0.83–1.71)

–

4.95 (4.50–5.60)

–

1.48 (1.27–1.69)

–

2.98 (2.51–3.44)

–

TC

100 (23.9)

1.25 (0.87–1.88)

0.787

5.22 (4.67–5.93)

0.090

1.52 (1.26–1.76)

0.319

3.10 (2.62–3.63)

0.278

CC

7 (1.7)

1.92 (0.85–2.33)

0.201

5.02 (4.68–6.20)

0.183

1.31 (1.21–1.59)

0.418

3.48 (3.16–4.06)

0.019

rs4767861

AA

137 (32.7)

1.23 (0.81–1.68)

–

4.94 (4.53–5.61)

–

1.51 (1.30–1.70)

–

3.00 (2.57–3.40)

–

GA

198 (47.3)

1.21 (0.86–1.79)

0.474

5.11 (4.45–5.64)

0.515

1.45 (1.24–1.70)

0.113

2.96 (2.46–3.54)

0.600

GG

84 (20.0)

1.21 (0.84–1.91)

0.134

5.16 (4.68–5.87)

0.123

1.41 (1.26–1.67)

0.236

3.13 (2.68–3.58)

0.132

  1. Differences between genotype groups were determined using analysis of covariance within each gender type, adjusted for age, BMI and waist circumference. P value in bold indicated the difference was significant comparing to the reference group (P<0.05).