Table 3 Top ten GO (Gene Ontology) and pathway categories enriched for co-expressed gene modules which correlated with obesity phenotypic traits
From: Gene expression profiling reveals distinct features of various porcine adipose tissues
Correlated trait | Tissue (Gene sets order No.) | Functional category | Term | P values | Involved gene No. |
|---|---|---|---|---|---|
Adipocyte volume | ULB (4) | GO-BP | metabolic process | 1.19 × 10-7 | 119 |
ILB (2) | GO-BP | coenzyme metabolic process | 8.84 × 10-6 | 8 | |
GO-BP | lipid metabolic process | 4.38 × 10-5 | 23 | ||
GO-BP | fatty acid metabolic process | 8.95 × 10-5 | 10 | ||
GO-BP | primary metabolic process | 1.07 × 10-4 | 104 | ||
GO-BP | translation | 5.37 × 10-4 | 12 | ||
GO-BP | protein folding | 1.50 × 10-3 | 8 | ||
GO-BP | fatty acid beta-oxidation | 2.65 × 10-3 | 3 | ||
GO-BP | pentose-phosphate shunt | 3.51 × 10-3 | 2 | ||
GO-BP | generation of precursor metabolites and energy | 4.15 × 10-3 | 9 | ||
Body density | RAD (8,11) | GO-BP | translation | 1.44 × 10-3 | 8 |
IAD (10) | GO-BP | protein targeting | 1.90 × 10-3 | 5 | |
GO-BP | lysosomal transport | 5.44 × 10-3 | 2 | ||
GO-MF | structural constituent of ribosome | 6.10 × 10-3 | 5 | ||
GO-MF | structural molecule activity | 6.62 × 10-3 | 15 | ||
GO-BP | nitrogen utilization | 1.20 × 10-2 | 1 | ||
KEGG | Serine glycine biosynthesis | 2.97 × 10-2 | 1 | ||
GO-BP | regulation of amino acid metabolic process | 3.55 × 10-2 | 1 | ||
GO-BP | pyrimidine base metabolic process | 4.40 × 10-2 | 2 | ||
GO-BP | pentose-phosphate shunt | 4.71 × 10-2 | 1 | ||
Apo-A1 (Metabolic indicators) | RAD (11) | GO-BP | nitrogen utilization | 3.51 × 10-3 | 1 |
GO-BP | regulation of amino acid metabolic process | 1.05 × 10-2 | 1 | ||
GO-BP | lysosomal transport | 3.12 × 10-2 | 1 | ||
GO-BP | nitrogen compound metabolic process | 3.12 × 10-2 | 1 | ||
GO-BP | neuromuscular synaptic transmission | 4.64 × 10-2 | 1 | ||
GO-MF | hormone activity | 1.55 × 10-2 | 2 | ||
KEGG | Vasopressin synthesis | 2.09 × 10-2 | 1 | ||
KEGG | De novo pyrmidineribonucleotidesbiosythesis | 3.12 × 10-2 | 1 | ||
KEGG | Cortocotropin releasing factor receptor signaling pathway | 5.14 × 10-2 | 1 | ||
KEGG | De novo purine biosynthesis | 5.64 × 10-2 | 1 | ||
HDL (Metabolic indicators) | RAD (1) | GO-BP | generation of precursor metabolites and energy | 1.20 × 10-15 | 37 |
GO-BP | metabolic process | 1.49 × 10-14 | 273 | ||
GO-BP | respiratory electron transport chain | 1.35 × 10-11 | 30 | ||
GO-BP | coenzyme metabolic process | 3.02 × 10-9 | 16 | ||
GO-BP | primary metabolic process | 9.31 × 10-9 | 241 | ||
GO-BP | signal transduction | 6.95 × 10-7 | 48 | ||
GO-BP | cell communication | 8.92 × 10-7 | 52 | ||
GO-BP | cell surface receptor linked signal transduction | 1.49 × 10-6 | 15 | ||
GO-BP | system development | 3.58 × 10-6 | 9 | ||
GO-BP | tricarboxylic acid cycle | 5.49 × 10-6 | 7 | ||
LDH (Metabolic indicators) | ULB (3) | GO-BP | fatty acid metabolic process | 1.37 × 10-5 | 9 |
GO-BP | metabolic process | 1.86 × 10-5 | 75 | ||
GO-BP | fatty acid beta-oxidation | 3.05 × 10-5 | 4 | ||
GO-BP | coenzyme metabolic process | 4.77 × 10-5 | 6 | ||
GO-BP | cellular amino acid biosynthetic process | 9.01 × 10-5 | 5 | ||
GO-BP | cellular amino acid metabolic process | 1.05 × 10-4 | 9 | ||
GO-BP | protein folding | 4.66 × 10-4 | 7 | ||
GO-BP | pentose-phosphate shunt | 1.45 × 10-3 | 2 | ||
GO-BP | primary metabolic process | 1.99 × 10-3 | 66 | ||
GO-BP | carbohydrate metabolic process | 2.94 × 10-3 | 12 | ||
Insulin (Metabolic indicators | RAD (3) | KEGG | VEGF signaling pathway | 3.72 × 10-4 | 4 |
GO-BP | transcription, RNA-dependent | 4.06 × 10-4 | 2 | ||
GO-BP | cell communication | 6.62 × 10-4 | 31 | ||
GO-BP | mesoderm development | 1.04 × 10-3 | 11 | ||
GO-BP | cellular process | 1.10 × 10-3 | 40 | ||
GO-BP | protein amino acid ADP-ribosylation | 1.11 × 10-3 | 2 | ||
GO-BP | signal transduction | 1.37 × 10-3 | 29 | ||
GO-BP | esicle-mediated transport | 1.69 × 10-3 | 11 | ||
GO-BP | system development | 1.93 × 10-3 | 14 | ||
GO-BP | cell surface receptor linked signal transduction | 4.81 × 10-3 | 16 | ||
IL-6 (Inflammatory and immune adipokines) | GOM (3) | GO-BP | immune system process | 6.66 × 10-4 | 21 |
IAD (11) | GO-BP | response to stimulus | 7.72 × 10-4 | 16 | |
GO-BP | response to interferon-gamma | 2.08 × 10-3 | 4 | ||
GO-BP | cellular defense response | 4.67 × 10-3 | 6 | ||
GO-BP | immune response | 6.84 × 10-3 | 8 | ||
GO-BP | DNA recombination | 1.06 × 10-2 | 3 | ||
GO-BP | nitrogen utilization | 1.16 × 10-2 | 1 | ||
GO-BP | gluconeogenesis | 1.35 × 10-2 | 2 | ||
GO-BP | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 1.81 × 10-2 | 2 | ||
KEGG | T cell activation | 1.84 × 10-2 | 4 | ||
TNF- α (Inflammatory and immune adipokines) | MAD (2) | GO-BP | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 4.26 × 10-5 | 4 |
GO-BP | antigen processing and presentation | 6.56 × 10-4 | 4 | ||
KEGG | T cell activation | 1.37 × 10-3 | 4 | ||
GO-BP | cellular defense response | 3.14 × 10-3 | 6 | ||
GO-BP | immune system process | 8.14 × 10-3 | 17 | ||
GO-BP | tRNAaminoacylation for protein translation | 2.18 × 10-2 | 2 | ||
KEGG | 5-Hydroxytryptamine biosynthesis | 3.17 × 10-2 | 1 | ||
KEGG | Mannose metabolism | 3.69 × 10-2 | 1 | ||
GO-BF | establishment or maintenance of chromatin architecture | 3.85 × 10-2 | 4 | ||
PAI-1 (Inflammatory and immune adipokines) | GOM(2) | GO-BP | immune system process | 6.00 × 10-15 | 41 |
GO-BP | response to stimulus | 6.31 × 10-15 | 30 | ||
GO-BP | cellular defense response | 1.25 × 10-10 | 15 | ||
GO-BP | immune response | 1.35 × 10-10 | 19 | ||
GO-BP | B cell mediated immunity | 1.05 × 10-7 | 9 | ||
GO-BP | natural killer cell activation | 4.17 × 10-6 | 7 | ||
GO-BP | antigen processing and presentation | 6.62 × 10-6 | 6 | ||
KEGG | T cell activation | 2.04 × 10-5 | 6 | ||
GO-BP | cell surface receptor linked signal transduction | 1.52 × 10-4 | 23 | ||
KEGG | Inflammation mediated by chemokine and cytokine signaling pathway | 3.11 × 10-4 | 8 |