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Table 3 Genotype and allele distributions in control subjects and patients with CAD in the Uygur population

From: The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China

 

Total

Men

Women

Variants

CAD n (%)

Control n (%)

P Value

CAD n (%)

Control n (%)

P Value

CAD n (%)

Control n(%)

P Value

rs4886605(SNP1)

         

Genotyping

         

CC

75(25.60%)

153(37.50%)

 

52(24.80%)

74(36.10%)

 

23(27.70%)

79(38.90%)

 

CT

162(55.30%)

191(46.80%)

 

121(57.60%)

104(50.70%)

 

41(49.40%)

87(42.90%)

 

TT

56(19.10%)

64(15.70%)

0.004*

37(17.60%)

27(13.20%)

0.036*

19(22.90%)

37(18.20%)

0.193

Dominant model

         

CC

75(25.60%)

153(37.50%)

 

52(24.80%)

74(36.10%)

 

23(27.70%)

79(38.90%)

 

TT + CT

218(74.40%)

255(62.50%)

0.001*

158(75.20%)

131(63.90%)

0.012*

60(72.30%)

124(61.10%)

0.073

Recessive model

         

TT

56(19.10%)

64(15.70%)

 

37(17.60%)

27(13.20%)

 

19(22.90%)

37(18.20%)

 

CC + CT

237(80.90%)

344(84.30%)

0.235

173(82.40%)

178(86.80%)

0.21

64(77.10%)

166(81.80%)

0.367

Additive model

         

CT

162(55.30%)

191(46.80%)

 

121(57.60%)

104(50.70%)

 

41(49.40%)

87(42.90%)

 

CC + TT

131(44.70%)

217(53.20%)

0.027*

89(42.40%)

101(49.30%)

0.159

42(50.60%)

116(57.10%)

0.313

Allele

         

C

312(53.24%)

497(60.91%)

 

225(53.57%)

252(61.46%)

 

87(52.41%)

245(60.34%)

 

T

274(46.76%)

319(39.09%)

0.006*

195(46.43%)

158(38.54%)

0.021*

79(47.59%)

161(39.66%)

0.081

rs12441817(SNP2)

         

Genotyping

         

CC

43(14.70%)

45(11.00%)

 

30(14.30%)

20(9.80%)

 

13(15.70%)

25(12.30%)

 

CT

150(51.20%)

178(43.60%)

 

110(52.40%)

92(44.90%)

 

40(48.20%)

86(42.40%)

 

TT

100(34.10%)

185(45.30%)

0.01*

70(33.30%)

93(45.40%)

0.034*

30(36.10%)

92(45.30%)

0.348

Dominant model

         

TT

100(34.10%)

185(45.30%)

 

70(33.30%)

93(45.40%)

 

30(36.10%)

92(45.30%)

 

CC + CT

193(65.90%)

223(54.60%)

0.003*

140(66.70%)

112(54.60%)

0.012*

53(63.90%)

111(54.70%)

0.154

Recessive model

         

CC

43(14.70%)

45(11.00%)

 

30(14.30%)

20(9.80%)

 

13(15.70%)

25(12.30%)

 

TT + CT

250(85.30%)

363(89.00%)

0.151

180(85.70%)

185(90.20%)

0.156

70(84.30%)

178(87.70%)

0.449

Additive model

         

CT

150(51.20%)

178(43.60%)

 

110(52.40%)

92(44.90%)

 

40(48.20%)

86(42.40%)

 

CC + TT

143(48.80%)

230(56.40%)

0.048*

100(47.60%)

113(55.10%)

0.126

43(51.80%)

117(57.60%)

0.368

Allele

         

C

236(40.27%)

268(32.84%)

 

170(40.48%)

132(32.20%)

 

66(39.78%)

136(33.50%)

 

T

350(59.73%)

548(67.16%)

0.004*

250(59.52%)

278(67.8%)

0.013*

100(60.22%

270(66.5%)

0.155

rs4646422(SNP3)

         

Genotyping

         

AA

251(85.7%)

350(85.80%)

 

178(84.80%)

177(86.30%)

 

73(88.00%)

173(85.20%)

 

AG

39(13.30%)

53(13.00%)

 

32(15.20%)

26(12.70%)

 

7(8.40%)

27(13.30%)

 

GG

3(1.00%)

5(1.20%)

0.963

0(0.00%)

2(1.00%)

0.319

3(3.60%)

3(1.50%)

0.291

Dominant model

         

AA

251(85.70%)

350(85.80%)

 

178(84.80%)

177(86.30%)

 

73(88.00%)

173(85.20%)

 

GG + AG

42(14.30%)

58(14.20%)

0.965

32(15.20%)

28(13.70%)

0.647

10(12.00%)

30(14.80%)

0.546

Recessive model

         

GG

3(1.00%)

5(1.20%)

 

0(0.00%)

2(1.00%)

 

3(3.60%)

3(1.50%)

 

AA + AG

290(99.00%)

403(98.80%)

0.803

210(100.00%)

203(99.00%)

0.243

80(96.40%)

200(98.50%)

0.275

Additive model

         

AG

39(13.30%)

53(13.00%)

 

32(15.20%)

26(12.70%)

 

7(8.40%)

27(13.30%)

 

AA + GG

254(86.70%)

355(87.00%)

0.901

178(84.80%)

179(87.30%)

0.453

76(91.60%)

176(86.70%)

0.248

Allele

         

A

541(92.32%)

753(92.28%)

 

388(92.38%)

380(92.68%)

 

153(92.17%)

373(91.87%)

 

G

45(7.68%)

63(7.72%)

0.977

32(7.62%)

30(7.31%)

0.869

13(7.83%)

33(8.13%)

0.906

rs1048943(SNP4)

         

Genotyping

         

CC

5(1.70%)

11(2.70%)

 

3(1.40%)

5(2.40%)

 

2(2.40%)

6(3.00%)

 

CT

85(29.00%)

112(27.50%)

 

63(30.00%)

54(26.30%)

 

22(26.50%)

58(28.60%)

 

TT

203(69.30%)

285(69.90%)

0.642

144(68.60%)

146(71.20%)

0.562

59(71.10%)

139(68.50%)

0.899

Dominant model

         

TT

203(69.30%)

285(69.90%)

 

144(68.60%)

146(71.20%)

 

59(71.10%)

139(68.50%)

 

CC + CT

90(30.70%)

123(30.20%)

0.872

66(31.40%)

59(28.70%)

0.557

24(28.90%)

64(31.60%)

0.664

Recessive model

         

CC

5(1.70%)

11(2.70%)

 

3(1.40%)

5(2.40%)

 

2(2.40%)

6(3.00%)

 

TT + CT

288(98.30%)

397(97.40%)

0.387

207(98.60%)

200(97.50%)

0.452

81(97.60%)

197(97.10%)

0.797

Additive model

         

CT

85(29.00%)

112(27.50%)

 

63(30.00%)

54(26.30%)

 

22(26.50%)

58(28.60%)

 

CC + TT

208(71.00%)

296(72.60%)

0.651

147(70.00%)

151(73.60%)

0.408

61(73.50%)

145(71.50%)

0.724

Allele

         

C

95(16.21%)

134(16.42%)

 

69(16.43%)

64(15.61%)

 

26(15.66%)

70(17.24%)

 

T

491(83.79%)

682(83.58%)

0.916

351(83.57%)

346(84.39%)

0.748

140(84.33%)

336(82.76%)

0.647

  1. CAD, coronary artery disease; SNP, single-nucleotide polymorphism; *P < 0.05.
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