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Figure 5 | Lipids in Health and Disease

Figure 5

From: The effect of two novel cholesterol-lowering agents, disodium ascorbyl phytostanol phosphate (DAPP) and nanostructured aluminosilicate (NSAS) on the expression and activity of P-glycoprotein within Caco-2 cells

Figure 5

P-gp protein expression in Caco-2 cells after treatment with NSAS. Cells were exposed for 24 hours to media alone (control), 10 μg/mL, 100 μg/mL and 500 μg/mL NSAS compound A. (A) Representative Western Blot. (B) The data represent the mean ± standard deviation of P-gp protein normalized by the protein expression of actin. There is no statistically significant difference between treatment groups and control. N = 3. (C) Expression profile of mdr-1 gene expression in Caco-2 cells. A sample from each PCR product was subjected to electrophoresis on a 1.5% agarose gel and the fluorescent bands were quantified with UVP-Labworks software. Each value represents the mean ± standard deviation of N = 3.

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