Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model

Table 3 Two-way analysis of variance (ANOVA) results for morphometric and metabolic profile of SHR vs. SHR- Lx rats with STRAIN and RA as major factors

Phenotype	STRAIN	ATRA	S*ATRA
Body weight	0.023	0.23	0.97
Liver, g/100 g b.wt.	0.0005	0.0008	0.76
Heart, g/100 g b.wt.	0.13	0.47	0.10
Kidney, g/100 g b.wt.	<0.0001	0.60	0.77
Adrenals, mg/100 g b.wt.	0.010	0.38	0.12
EFP wt., g/100 g b.wt.	0.039	0.65	0.90
RFP wt., g/100 g b.wt.	0.13	0.64	0.96
Total C	0.0018	0.56	0.07
Chylomicron C	0.48	0.0003	0.001
VLDL-C	0.43	<0.0001	0.0007
LDL-C	0.011	0.31	0.010
HDL-C	0.0035	0.06	0.96
Total TG	0.37	0.0003	0.017
Chylomicron TG	0.59	<0.0001	<0.0001
VLDL-TG	0.31	0.0049	0.12
LDL-TG	0.97	0.017	0.77
HDL-TG	0.85	0.0030	0.013
Glycerol	0.13	0.41	0.37
Fasting plasma glucose	0.15	0.08	0.76
Lipoprotein particle size
VLDL-TG	0.61	0.34	0.0075
LDL-C	0.0026	0.0013	0.07
HDL-C	0.0003	0.039	0.08

The significance levels of two-way ANOVA’s STRAIN, RA and STRAIN*RA (S*RA) factor interactions are shown (significant p values in bold, non-significant in italics).

ISSN: 1476-511X