The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population

Lee, Tammy C; Ivester, Priscilla; Hester, Austin G; Sergeant, Susan; Case, Larry Douglas; Morgan, Timothy; Kouba, Ethel O; Chilton, Floyd H

doi:10.1186/1476-511X-13-196

Lipids in Health and Disease

Table 2 Impact of dietary oil supplements on serum fatty acid

From: The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population

Serum fatty acid profile	CO			BO			FO
	Baseline^*(SD)	Post-oil^*(SD)	p-value	Baseline^*(SD)	Post-oil^*(SD)	p-value	Baseline^*(SD)	Post-oil^*(SD)	p-value
Cl4:0	0.70 (0.07)	0.66 (0.05)	0.56	0.69 (0.08)	0.66 (0.04)	0.86	0.72 (0.07)	0.62 (0.06)	0.78
C14:1	0	0		0	0		0	0
C15:0	0.15 (0.02)	0.14 (0.02)	0.58	0.13 (0.02)	0.14 (0.02)	0.46	0.16 (0.02)	0.14 (0.02)	0.38
C15:1	0	0		0	0		0	0
C16:0	21.19 (0.40)	20.75 (0.37)	0.23	20.64 (0.41)	20.49 (0.37)	0.71	21.65 (0.47)	20.76 (0.39)	0.51
C16:1 n-7	1.68 (0.13)	1.57 (0.13)	0.23	1.58 (0.08)	1.39 (0.08)	0.03	1.92 (0.24)	1.55 (0.14)	0.002
C17:1	0.08 (0.02)	0.04 (0.02)	0.24	0.10 (0.02)	0.05 (0.02)	0.05	0.13 (0.03)	0.06 (0.02)	0.05
C18:0	7.47 (0.09)	7.62 (0.12)	0.21	7.23 (0.14)	7.55 (0.16)	<0.001	7.00 (0.25)	7.39 (0.27)	0.02
C18:1	0.21 (0.06)	0.25 (0.05)	0.21	0.12 (0.07)	0.13 (0.05)	0.63	0.17 (0.06)	0.25 (0.06)	0.02
C18:1 n-9	20.63 (0.96)	20.30 (0.61)	0.15	20.22 (0.51)	19.60 (0.44)	0.10	21.92 (0.98)	20.24 (0.52)	0.004
C18:1 n-11	1.60 (0.06)	1.51 (0.06)	0.03	1.50 (0.07)	1.44 (0.05)	0.94	1.84 (0.06)	1.56 (0.06)	<0.001
C18:2 n-6 [LA]	31.99 (1.26)	33.11 (0.93)	<0.001	32.67 (0.98)	30.97 (0.80)	0.002	29.71 (1.28)	29.94 (1.14)	0.86
C18:3 n-6 [GLA]	0.53 (0.03)	0.52 (0.03)	0.32	0.59 (0.04)	1.20 (0.08)	<0.001	0.55 (0.05)	0.45 (0.05)	0.01
C18:3 n-3 [ALA]	0.73 (0.06)	0.71 (0.05)	0.85	0.80 (0.05)	1.05 (0.05)	<0.001	0.77 (0.09)	0.83 (0.06)	0.16
C18:4 n-3 [SDA]	0.03 (0.02)	0.01 (0.00)	0.82	0.01 (0.01)	0.08 (0.01)	0.003	0.01 (0.01)	0.02 (0.01)	0.69
C20:0	0.01 (0.01)	0.01 (0.00)	0.81	0.00 (0.00)	0.00) (0.00)	1.00	0.00 (0.00)	0.00 (0.00)	1.00
C20:1 n-9	0.08 (0.02)	0.05 (0.01)	0.09	0.04 (0.01)	0.04 (0.01)	0.83	0.10 (0.02)	0.03 (0.01)	0.01
C20:2 n-6	0.30 (0.02)	0.31 (0.01)	0.72	0.32 (0.01)	0.24 (0.01)	<0.001	0.33 (0.02)	0.23 (0.18)	<0.001
C20:3 n-6 [DGLA]	1.68 (0.08)	1.61 (0.05)	0.32	1.51 (0.08)	1.97 (0.09)	<0.001	1.43 (0.09)	1.45 (0.07)	0.002
C20:4 n-6 [AA]	8.17 (0.56)	8.11 (0.46)	0.83	9.12 (0.40)	9.16 (0.34)	0.05	8.68 (0.40)	7.31 (0.36)	<0.001
C20:5 n-3 [EPA]	0.48 (0.04)	0.46 (0.05)	0.28	0.573 (0.05)	0.89 (0.08)	<0.001	0.56 (0.07)	2.79 (0.18)	<0.001
C22:0	0	0		0	0		0	0
C22:1 n-9	0.05 (0.04)	0.11 (0.04)	0.20	0.00 (0.00)	0.15 (0.06)	0.008	0.00 (0.00)	0.19 (0.11)	0.03
C22:2 n-6	0	0		0	0		0	0
C22:5 n-3 [DPA]	0.54 (0.03)	0.51 (0.03)	0.25	0.55 (0.02)	0.65 (0.02)	<0.001	0.59 (0.03)	0.89 (0.03)	<0.001
C24:0	0.02 (0.02)	0.02 (0.01)	0.81	0.02 (0.02)	0.01 (0.01)	0.88	0.00 (0.00)	0.01 (0.01)	1.00
C22:6 n-3 [DHA]	1.71 (0.12)	1.60 (0.11)	0.13	1.63 (0.10)	1.58 (0.11)	0.56	1.73 (0.016)	3.58 (0.11)	<0.001
C24:1 n-9	0.03 (0.02)	0.01 (0.01)	0.25	0.01 (0.01)	0.00 (0.00)	0.50	0.04 (0.02)	0.00 (0.00)	0.25

*% total fatty acids.
Data are the mean (SD) at baseline and after oil supplementation (combined 4- and 8-week data). Pre – post changes within a supplementation arm that reached statistical significance are shown by a bolded p-value.

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