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Table 1 Weight gain and liver percentage relative to body weight in rats with cholesterol-rich diet, atorvastatin and with or without coenzyme Q 10 supplementation

From: Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet

 

CD

CD + ATV2(0.56 /day)

HD

HD + ATV1(0.2 g/day)

HD + ATV2(0.56 mg/day)

HD + ATV3(1.42 mg/day)

Body weight gain (g)

      

Without CoQ10

114 ± 20

126 ± 23

140 ± 4ª

130 ± 7

135 ± 24

104 ± 38

With CoQ10

95 ± 71

102 ± 361

117 ± 8a,1

77 ± 28b,1

108 ± 61

96 ± 8b,1

Liver percentage

      

Relative to body weight (%)

      

Without CoQ10

2.9 ± 0.2

2.7 ± 0.1a

4.7 ± 1.3a

4.5 ± 0.3

4.3 ± 0.3

4.3 ± 0.5

With CoQ10

2.38 ± 0.11

3.2 ± 0.1a, 1

3.92 ± 1.1a

3.9 ± 0.11

3.08 ± 0.13b, 1

3.2 ± 0.18b, 1

  1. CD, control diet; CD + ATV2, CD + atorvastatin 0.56 mg/day; HD, hypercholesterolemic diet; HD + ATV1, 0.2 mg/day; HD + ATV2 0.56 mg/day; HD + ATV3 1.42 mg/day, Coenzyme Q10, 0.57 mg/day; Data are expressed as mean ± S.E.M.; n = 8. One-way analysis of variance (ANOVA) (groups CD, CD + ATV2, HD, HD + ATV1, HD + ATV2, HD + ATV3) accompanied by the Student-Newman-Keuls test and differences between the groups were determined by the Student's t test (Without CoQ10 vs With CoQ10) (p < 0.05). aStatistically different from CD (p < 0.05); bstatistically different from either HD or HD + CoQ10 (p < 0.05); 1statistically different from the same group without CoQ10.