Skip to main content

Table 4 Effect of a cholesterol-rich diet and atorvastatin with or without coenzyme Q 10 supplementation on the liver mitochondrial respiratory control index

From: Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet

Respiratory control

CD

CD + ATV2

HD

HD + ATV1

HD + ATV2

HD + ATV3

  

(0.56 mg/day)

 

(0.2 mg/day)

(0.56 g/day)

(1.42 mg/day)

Without CoQ10

2.98 ± 0.06

2.25 ± 0.25a

2.02 ± 0.51a

2.93 ± 0.27b

1.85 ± 0.15

2.38 ± 0.35

With CoQ10

3.20 ± 0.151

4.69 ± 0.27a,1

3.68 ± 0.21a,1

2.72 ± 0.40b

3.55 ± 0.021

3.13 ± 0.221

  1. CD, control diet; CD + ATV2, CD + atorvastatin 0.56 mg/day; HD, hypercholesterolemic diet; HD + ATV1, 0.2 mg/day; HD + ATV2 0.56 mg/day; HD + ATV3 1.42 mg/day, Coenzyme Q10, 0.57 mg/day; Data are expressed as mean ± S.E.M.; n = 8. One-way analysis of variance (ANOVA) (groups CD, CD + ATV2, HD, HD + ATV1, HD + ATV2, HD + ATV3) accompanied by the Student-Newman-Keuls test and differences between the groups were determined by the Student's t test (Without CoQ10 vs With CoQ10) (p < 0.05). aStatistically different from either CD or CD + CoQ10 (p < 0.05); bstatistically different from either HD or HD + CoQ10 (p < 0.05); 1statistically different from the same group without CoQ10.
Back to article page

Lipids in Health and Disease

ISSN: 1476-511X