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Table 1 Effects of dietary supplementation with SAqFSC-P, PAqFSC-P, or bicyclol on serum lipoprotein profiles in normal and hypercholesterolemic mice

From: Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet

Groups Drug concentration (%, w/w) HDL (mmol/L) LDL (mmol/L) HDL/LDL (mmol/L) LDL/HDL (mmol/L) N-HDL (mmol/L)
Normal mice       
Control ND - 3.94 ± 0.21 0.71 ± 0.04 5.82 ± 0.34 0.18 ± 0.01 0.11 ± 0.11
SAqFSC-P/ND 1 3.95 ± 0.09 0.67 ± 0.03 6.02 ± 0.28 0.17 ± 0.01 0.23 ± 0.13
  9 4.00 ± 0.11 0.63 ± 0.04 6.47 ± 0.30 0.16 ± 0.01 0.25 ± 0.09
PAqFSC-P/ND 1 4.00 ± 0.15 0.63 ± 0.03 6.20 ± 0.36 0.16 ± 0.01 0.23 ± 0.06
  9 4.18 ± 0.17 0.63 ± 0.03 6.46 ± 0.29 0.16 ± 0.01 0.17 ± 0.06
Bicyclol/ND 0.025 4.17 ± 0.16 0.70 ± 0.04 6.21 ± 0.48 0.17 ± 0.02 0.10 ± 0.07
Hypercholester-olemic mice       
Control ND - 3.10 ± 0.12 0.20 ± 0.02 16.65 ± 1.30 0.06 ± 0.01 0.64 ± 0.03
Control HCBD - 3.02 ± 0.12 1.08 ± 0.07a 2.86 ± 0.17a 0.36 ± 0.02a 2.54 ± 0.14a
SAqFSC-P/HCBD 1 3.15 ± 0.15 1.08 ± 0.06 3.29 ± 0.16 0.31 ± 0.02 2.17 ± 0.12
  3 3.20 ± 0.12 1.22 ± 0.09 2.90 ± 0.14 0.35 ± 0.02 2.51 ± 0.19
PAqFSC-P/HCBD 1 3.16 ± 0.10 1.09 ± 0.06 2.72 ± 0.17 0.37 ± 0.02 2.18 ± 0.10b
  3 3.08 ± 0.10 0.93 ± 0.05 3.30 ± 0.21 0.35 ± 0.02 1.98 ± 0.11b
Bicyclol/HCBD 0.025 3.27 ± 0.14 1.02 ± 0.07 3.41 ± 0.23 0.31 ± 0.02 2.28 ± 0.13
  1. Experimental details were described in Figure1. Mice were fed with ND or HCBD containing SAqFSC-P, PAqFSC-P, or bicyclol at the indicated concentration for 10 days. Serum low-density lipoprotein (LDL), high-density lipoprotein (HDL), HDL/LDL, LDL/HDL, and N-HDL levels were then measured. Mouse model of hypercholesterolemia was generated by HCBD. Values given are the means ± S.E.M., with n = 10. aP < 0.01 vs. control ND; bP < 0.05 vs. control HCBD, using a one-way ANOVA follow by Dunnett’s multiple comparisons test or post-hoc analysis.