Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet

Table 3 Effects of dietary supplementation with SAqFSC-P, PAqFSC-P, or bicyclol on body weight gain and food/drug intake in normal and hypercholesterolemic mice

Groups	Drug concentration (%, w/w)	Body weight gain (g)		Food intake (g/kg/day)	Drug intake (g/kg/day)
Groups	Drug concentration (%, w/w)	D 1 → D 5	D 5 → D 10	Food intake (g/kg/day)	Drug intake (g/kg/day)
*Normal mice*
Control ND	-	7.41 ± 0.29	4.46 ± 0.22	156.4	-
SAqFSC-P/ND	1	7.52 ± 0.07	3.41 ± 0.18^a	142.2	1.42
	9	7.19 ± 0.16	3.53 ± 0.27^a	157.5	14.18
PAqFSC-P/ND	1	7.42 ± 0.17	3.99 ± 0.36	143.7	1.44
	9	7.49 ± 0.35	4.54 ± 0.26	151.4	13.63
Bicyclol/ND	0.025	7.41 ± 0.20	3.70 ± 0.26^a	158.3	0.04
*Hypercholesterolemic mice*
Control ND	-	10.42 ± 0.25	3.04 ± 0.14	162.7	-
Control HCBD	-	9.76 ± 0.16^a	2.81 ± 0.12	151.0	-
SAqFSC-P/HCBD	1	9.71 ± 0.29	3.02 ± 0.10	151.4	1.51
	3	9.36 ± 0.20	2.98 ± 0.19	150.0	4.50
PAqFSC-P/HCBD	1	10.02 ± 0.28	2.78 ± 0.11	150.5	1.51
	3	9.66 ± 0.15	3.11 ± 0.16	157.5	4.72
Bicyclol/HCBD	0.025	10.36 ± 0.23	2.72 ± 0.13	152.5	0.04

Experimental details were described in Figure1. The dosages (g/kg/day, based on crude herbal material) were determined with respect to the amount of ingested diet (g/day/kg) and drug concentration in the diet. Values given are the means ± S.E.M., with n = 10. ^aP < 0.05 vs. control ND, using a one-way ANOVA followed by Dunnett’s multiple comparisons test or post-hoc analysis.

ISSN: 1476-511X