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Table 1 Differentially expressed proteins and mRNA abundances of genes in the small intestinal mucosa of VDR-KO relative to WT mice

From: Vitamin D receptor regulates intestinal proteins involved in cell proliferation, migration and stress response

UniProtAcc. Protein Spot no. Fold changea No. of peptides Coverage (%) pI (theor.) Mascot score mRNA fold changea Function
P14206 37/67 kDa laminin receptor (37/67LR) 16 +10.8 9 39 4.80 422 n.s. Membrane receptor for laminin
P08113 94 kDa glucose-regulated protein (GRP94) 18, 19 +5.0, +5.5 22 28 4.74 307 -1.4* Chaperone, stress response
P21107 Tropomyosin 3 (Tpm3) 13 +4.3 11 28 4.68 225 n.d. Cytoskeleton
Q04857 Collagen type VI (alpha 1 chain) (Col6a1) 1 +4.2 9 10 5.20 88 +1.8* Extracellular matrix protein
Q01853 Valosin-containing protein(VCP/p97) 17 +3.8 18 28 5.14 204 n.s. Chaperon, stress response, protein degradation
P97372 Proteasome activator complex subunit 2 (PA28β) 8 +3.1 8 40 5.54 35c -1.6* Proteasome activation
P19001 Keratin, type I cytoskeletal 19 (K19) 14, 15 +2.1, +2.9 14 39 5.28 127 n.s. Cytoskeleton
Q60604 Adseverin 2 +2.8 18 30 5.46 88 n.s. Cytoskeleton
P60710 β-actin 5, 6, 7 -6.5, -4.2-4.1 5 15-21 5.29b 54-70 -2.0* Cytoskeleton
Q9CQ60 6-phosphogluconolactonase (6PGL) 9 -2.7 3 15 5.55 39c n.s. Carbohydrate metabolism
P63017 Heat shock cognate 71 kDa protein (Hsc70) 3, 4 -2.5, -2.6 31 52 5.37 586 n.s. Chaperone, stress response
P51162 Ileal lipid-binding protein (ILBP) 10 -2.5 8 68 5.91 210 n.d. Lipid metabolism
P55050 Fatty acid-binding protein 2 (I-FABP) 11 -2.4 4 31 6.62 102 n.s. Lipid metabolism
P63101 14-3-3 protein ζ/δ 12 -2.3 18 63 4.73 353 -1.6* Signal transduction
  1. a)“+” indicates up- and “–“ down-regulation in VDR-KO vs. WT mice; b)full length protein; c)below Mascot significance threshold of 56; *)Significantly different from WT mice (p < 0.05, Student’s t-test); n.s. non-significant; n.d. not determined.