Differential patterns of insulin secretion and sensitivity in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease versus patients with type 2 diabetes mellitus alone

Table 3 Multiple linear regression analysis of plasma glucose with each of the dependent variables

		Fasting		AUC PG		AUC PG		AUC PG
		(PG 0 min)		0–30 min		30–120 min		120–180 min
		*Bate*	*Sig*	*Bate*	Sig	*Bate*	*Sig*	*Bate*	*Sig*
T2DM + NAFLD	Insulin sensitivity	0.634	0.001*	0.625	0.001*	0.378	0.057	0.042	0.839
T2DM + NAFLD	Insulin secretion	-0.545	0.004*	0.118	0.566	-0.355	0.075	-0.570	0.002*
T2DM	Insulin sensitivity	0.413	0.036*	0.099	0.629	0.038	0.855	0.155	0.449
T2DM	Insulin secretion	-0.626	0.001*	-0.227	0.265	-0.413	0.036*	-0.657	0.000*

The variation in the OGTT with each of the dependent variables: Insulin sensitivity = HOMA-IR, muscle insulin sensitivity index; Insulin secretion = ΔC-p/PG 30 min ratio, ΔC-p/PG 30 min ratio, AUC C-p/PG 30–120 min ratio, AUC C-p/PG 120–180 min. *, P < 0.05.

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