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Figure 1 | Lipids in Health and Disease

Figure 1

From: Long-term probucol therapy continues to suppress markers of neurovascular inflammation in a dietary induced model of cerebral capillary dysfunction

Figure 1

Semi-quantitative 3-D immunomicroscopy for the assessment of blood–brain barrier integrity. The integrity of blood–brain barrier (BBB) in mice maintained on low-fat (LF) control chow or diet enriched in saturated fatty acids (SFA) with or without probucol for 3 months (3 M) and 12 months (12 M) was assessed by the cerebral extravasation of plasma proteins, IgG and apolipoprotein (apo) B. (A) 3-D quantitative immunomicroscopy graphs show the mean voxel intensity of IgG/apoB that are in the parenchyme of cortex (CTX) and hippocampal formation (HPF). The * shows the statistical significance assessed by one-way ANOVA with Tukey’s post hoc test (p < 0.05, n = 8). (B) Representative images of capillary vessel integrity are provided. IgG is shown in green, apolipoprotein (apo) B is in red, and nuclei are in blue. The scale bar indicates 100 μm.

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Lipids in Health and Disease

ISSN: 1476-511X