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Figure 1 | Lipids in Health and Disease

Figure 1

From: Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress

Figure 1

Atorvastatin improves the β-cell sensitivity to glucose in obese C57 mice and decreases fasting insulin level. Pancreatic beta cell function was evaluated by hyperglycemic clamp. After sampling (t = 0 min) for the assay of the basal blood glucose and insulin, animals received intravenously glucose bolus followed by a constant infusion of glucose to maintain plasma glucose level at 14 mmol/l. (A) Plasma glucose level, (B) Glucose infusion rates (GIR), (C) Plasma insulin level, (D) Insulin stimulation ratio, and (E) fasting insulin level. Results are means ± S.E.M. (n = 4-5). *P < 0.05, **P < 0.01 vs. control.

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Lipids in Health and Disease

ISSN: 1476-511X