production in 3T3-Swiss fibroblasts n = 3, ± SD). The addition incubation of nitric oxide synthase inhibitor decreased the LPS induced PGE2 production in 3T3-Swiss fibroblasts. Cells were incubated for 48 hr with bovine serum albumin alone as control or bovine serum albumin-soap loaded fatty acids (25 μM). Medium was then replaced with fresh fatty acid enriched medium containing lipopolysaccharide (LPS, 10 μg/ml) with or without NG-nitro-L-arginine methyl ester (L-NAME, 10-7 M) for another 24 hr. The wound was created after initial 48 hr treatments in duplicate set of plate with or without LPS. Culture supernatants were collected at 24 hr post wounding and the quantification of PGE2performed. The results were presented as the PGE2 concentration (pg/ml). Bars with different letters are significantly different (P < 0.05). EPA, eicosapentaenoic acid; AA, arachidonic acid; LPS, lipopolysaccharide; L-NAME, NG-nitro-L-arginine methyl ester.