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Table 4 Clinical and biochemical features according to NPC1L1 haplotype

From: NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe

haplotype
  2/2 2/X X/X P-value
number 37 51 13  
age (years) 56.6 ± 13.3 53.9 ± 11.3 58.4 ± 6.9 NS
percent female 48.6 37.3 38.5 NS
percent on statin 65.8 70.6 69.8 NS
baseline plasma lipids and lipoproteins (mmol/L)
   cholesterol     
   - total 6.88 ± 1.33 6.31 ± 1.59 6.73 ± 1.01 NS
   - LDL 4.64 ± 1.39 4.41 ± 1.51 4.49 ± 1.10 NS
   - HDL 1.16 ± 0.34 1.19 ± 0.29 1.20 ± 0.21 NS
triglycerides 2.58 ± 1.75 1.99 ± 1.37 3.47 ± 3.78 NS
percent change on-treatment
   cholesterol     
   - total -16.5 ± 12.2 -15.8 ± 13.0 -22.8 ± 8.4 NS (0.07)
   - LDL -23.6 ± 13.2 -23.6 ± 14.7 -35.2 ± 13.5 0.02
   - HDL +10.7 ± 43.0 +1.2 ± 14.3 +0.6 ± 17.0 NS
   triglycerides -4.2 ± 35.6 +2.9 ± 44.9 -0 ± 30.3 NS
  1. abbreviations: as in Table 1.