Table 4 Clinical and biochemical features according to NPC1L1 haplotype

2/2

2/X

X/X

P-value

number

37

51

13

age (years)

56.6 ± 13.3

53.9 ± 11.3

58.4 ± 6.9

NS

percent female

48.6

37.3

38.5

NS

percent on statin

65.8

70.6

69.8

NS

baseline plasma lipids and lipoproteins (mmol/L)

   cholesterol

   - total

6.88 ± 1.33

6.31 ± 1.59

6.73 ± 1.01

NS

   - LDL

4.64 ± 1.39

4.41 ± 1.51

4.49 ± 1.10

NS

   - HDL

1.16 ± 0.34

1.19 ± 0.29

1.20 ± 0.21

NS

triglycerides

2.58 ± 1.75

1.99 ± 1.37

3.47 ± 3.78

NS

percent change on-treatment

   cholesterol

   - total

-16.5 ± 12.2

-15.8 ± 13.0

-22.8 ± 8.4

NS (0.07)

   - LDL

-23.6 ± 13.2

-23.6 ± 14.7

-35.2 ± 13.5

0.02

   - HDL

+10.7 ± 43.0

+1.2 ± 14.3

+0.6 ± 17.0

NS

   triglycerides

-4.2 ± 35.6

+2.9 ± 44.9

-0 ± 30.3

NS