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Table 2 Statistical significance of fasting serum glucose level and lipid profile in hypercholesterolemic rats treated with bezafibrate, quinazolinone and halogenated derivatives, compared to control group.

From: The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats

Parameters HCD HCD+B HCD+Q HCD+BrQ HCD+IQ
Glucose(mg/dl)      
Mean ± SD 123.57 ± 11.99a 109.20 ± 14.31b 86.77 ± 9.87c 95.80 ± 8.28c 87.24 ± 5.32c
Range (105.11–135.02) (82.69–125.22) (77.45–106.22) (86.36–111.10) (77.54–93.81)
Change% - -11.63 -29.78 -22.47 -29.40
Total lipids(g/L)      
Mean ± SD 4.58 ± 0.67a 3.75 ± 0.68b 3.31 ± 0.95b 3.13 ± 0.43b 3.10 ± 0.78b
Range (3.62–5.67) (2.82–4.79) (2.02–4.54) (2.40–3.90) (2.17–4.72)
Change% - -18.12 -27.73 -31.66 -32.31
T.G.(mg/dl)      
Mean ± SD 94.46 ± 14.23a 69.29 ± 11.04b 87.05 ± 9.18ac 78.56 ± 12.79bc 79.59 ± 15.94bc
Range (73.33–108.89) (54.40–86.65) (75.56–102.22) (66.67–98.50) (52.44–100.89)
Change% - -26.65 -7.84 -16.83 -15.74
T.Cholesterol(mg/dl)      
Mean ± SD 159.06 ± 26.04a 113.28 ± 17.52b 95.55 ± 18.11bc 93.19 ± 14.29bc 89.35 ± 22.37c
Range (119.35–87.50) (95.93–139.06) (75.63–121.41) (65.63–104.69) (70.31–123.44)
Change% - -28.78 -39.93 -41.41 -43.83
F.Cholesterol(mg/dl)      
Mean ± SD 36.66 ± 7.14a 37.88 ± 8.94a 32.12 ± 8.15a 29.45 ± 4.11a 30.14 ± 6.39a
Range (25.76–45.20) (29.59–52.36) (21.14–46.18) (22.11–33.82) (25.04–40.33)
Change% - 3.33 -12.38 -19.67 -17.79
E.Cholesterol(mg/dl)      
Mean ± SD 122.40 ± 19.10a 76.25 ± 8.89b 63.93 ± 10.02bc 65.05 ± 7.96bc 60.25 ± 15.29c
Range (91.85–142.30) (66.01–89.04) (50.54–76.01) (54.00–74.33) (43.32–83.11)
Change% - -37.7 -47.77 -46.85 -50.78
HDL-C (mg/dl)      
Mean ± SD 24.27 ± 3.23 a 27.73 ± 5.48a 28.33 ± 6.15a 25.68 ± 6.34a 21.14 ± 8.93a
Range (19.75–28.80) (18.30–35.15) (20.36–36.00) (18.92–33.32) (14.44–37.84)
Change% - 14.26 16.73 5.81 -12.90
LDL-C (mg/dl)      
Mean ± SD 116.09 ± 26.74a 71.32 ± 17.78 b 52.20 ± 15.23b 51.49 ± 10.43 b 52.89 ± 19.31b
Range (74.82–141.75) (49.96–89.66) (32.83–76.84) (29.54–62.17) (26.84–79.28)
Change% - -38.56 -55.03 -55.65 -54.44
VLDL-C (mg/dl)      
Mean ± SD 18.89 ± 2.85a 13.86 ± 2.21b 17.41 ± 1.84ac 15.71 ± 2.56bc 15.92 ± 3.19bc
Range (14.67–21.78) (10.88–17.33) (15.11–20.44) (13.33–19.70) (10.49–20.18)
Change% - -26.63 -7.83 -16.83 -15.72
A.I.      
Mean ± SD 5.57 ± 0.87a 3.27 ± 1.30b 2.41 ± 0.42b 2.79 ± 1.02b 3.47 ± 0.91b
Range (4.22–7.21) (1.80–6.11) (1.94–3.14) (1.67–4.52) (2.26–4.70)
Change% - -41.29 -56.73 -49.91 -37.70
  1. For each parameter similar characters denote insignificance between groups. The mean difference is significant at p < 0.05.