Table 2 Statistical significance of fasting serum glucose level and lipid profile in hypercholesterolemic rats treated with bezafibrate, quinazolinone and halogenated derivatives, compared to control group.

Glucose(mg/dl)

Mean ± SD

123.57 ± 11.99^a

109.20 ± 14.31^b

86.77 ± 9.87^c

95.80 ± 8.28^c

87.24 ± 5.32^c

Range

(105.11–135.02)

(82.69–125.22)

(77.45–106.22)

(86.36–111.10)

(77.54–93.81)

Change%

-

-11.63

-29.78

-22.47

-29.40

Total lipids(g/L)

Mean ± SD

4.58 ± 0.67^a

3.75 ± 0.68^b

3.31 ± 0.95^b

3.13 ± 0.43^b

3.10 ± 0.78^b

Range

(3.62–5.67)

(2.82–4.79)

(2.02–4.54)

(2.40–3.90)

(2.17–4.72)

Change%

-

-18.12

-27.73

-31.66

-32.31

T.G.(mg/dl)

Mean ± SD

94.46 ± 14.23^a

69.29 ± 11.04^b

87.05 ± 9.18^ac

78.56 ± 12.79^bc

79.59 ± 15.94^bc

Range

(73.33–108.89)

(54.40–86.65)

(75.56–102.22)

(66.67–98.50)

(52.44–100.89)

Change%

-

-26.65

-7.84

-16.83

-15.74

T.Cholesterol(mg/dl)

Mean ± SD

159.06 ± 26.04^a

113.28 ± 17.52^b

95.55 ± 18.11^bc

93.19 ± 14.29^bc

89.35 ± 22.37^c

Range

(119.35–87.50)

(95.93–139.06)

(75.63–121.41)

(65.63–104.69)

(70.31–123.44)

Change%

-

-28.78

-39.93

-41.41

-43.83

F.Cholesterol(mg/dl)

Mean ± SD

36.66 ± 7.14^a

37.88 ± 8.94^a

32.12 ± 8.15^a

29.45 ± 4.11^a

30.14 ± 6.39^a

Range

(25.76–45.20)

(29.59–52.36)

(21.14–46.18)

(22.11–33.82)

(25.04–40.33)

Change%

-

3.33

-12.38

-19.67

-17.79

E.Cholesterol(mg/dl)

Mean ± SD

122.40 ± 19.10^a

76.25 ± 8.89^b

63.93 ± 10.02^bc

65.05 ± 7.96^bc

60.25 ± 15.29^c

Range

(91.85–142.30)

(66.01–89.04)

(50.54–76.01)

(54.00–74.33)

(43.32–83.11)

Change%

-

-37.7

-47.77

-46.85

-50.78

HDL-C (mg/dl)

Mean ± SD

24.27 ± 3.23 ^a

27.73 ± 5.48^a

28.33 ± 6.15^a

25.68 ± 6.34^a

21.14 ± 8.93^a

Range

(19.75–28.80)

(18.30–35.15)

(20.36–36.00)

(18.92–33.32)

(14.44–37.84)

Change%

-

14.26

16.73

5.81

-12.90

LDL-C (mg/dl)

Mean ± SD

116.09 ± 26.74^a

71.32 ± 17.78 ^b

52.20 ± 15.23^b

51.49 ± 10.43 ^b

52.89 ± 19.31^b

Range

(74.82–141.75)

(49.96–89.66)

(32.83–76.84)

(29.54–62.17)

(26.84–79.28)

Change%

-

-38.56

-55.03

-55.65

-54.44

VLDL-C (mg/dl)

Mean ± SD

18.89 ± 2.85^a

13.86 ± 2.21^b

17.41 ± 1.84^ac

15.71 ± 2.56^bc

15.92 ± 3.19^bc

Range

(14.67–21.78)

(10.88–17.33)

(15.11–20.44)

(13.33–19.70)

(10.49–20.18)

Change%

-

-26.63

-7.83

-16.83

-15.72

A.I.

Mean ± SD

5.57 ± 0.87^a

3.27 ± 1.30^b

2.41 ± 0.42^b

2.79 ± 1.02^b

3.47 ± 0.91^b

Range

(4.22–7.21)

(1.80–6.11)

(1.94–3.14)

(1.67–4.52)

(2.26–4.70)

Change%

-

-41.29

-56.73

-49.91

-37.70