Skip to main content

Table 5 Statistical significance of hepatic lipid profile and malondialdehyde concentration in diabetic-hypercholesterolemic rats treated with bezafibrate, quinazolinone and halogenated derivatives

From: The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats

Parameters C C+B C+Q C+BrQ C+IQ
Total lipids      
Mean ± SD 74.76 ± 7.34a 65.00 ± 7.37a 71.37 ± 6.01a 65.93 ± 11.54a 66.12 ± 9.47a
Range (65.88–84.71) (54.90–76.47) (62.16–77.65) (45.49–81.57) (48.92–78.43)
Change% - -13.06 -4.53 -11.81 -11.56
Triacylglycerol      
Mean ± SD 12.10 ± 3.37a 9.90 ± 1.08a 11.90 ± 4.38a 12.03 ± 5.07a 11.80 ± 4.82a
Range (8.87–17.30) (8.38–11.30) (7.48–16.61) (6.09–18.78) (6.23–17.30)
Change% - -18.18 -1.65 -0.58 -2.48
Total cholesterol      
Mean ± SD 26.53 ± 4.93a 26.58 ± 3.37a 23.87 ± 3.58a 25.62 ± 2.94a 26.57 ± 2.88a
Range (20.05–34.15) (21.14–31.71) (18.79–28.86) (23.58–32.52) (22.08–30.08)
Change% - 0.19 -10.03 -3.43 0.15
Free cholesterol      
Mean ± SD 7.34 ± 2.45a 7.49 ± 1.93a 12.15 ± 2.42b 12.40 ± 3.17b 12.29 ± 2.59b
Range (4.04–10.41) (5.69–11.32) (8.29–16.03) (8.85–18.31) (8.98–14.80)
Change% - 2.04 65.53 68.94 67.44
Cholesterol ester      
Mean ± SD 19.19 ± 2.61a 19.19 ± 1.95a 12.93 ± 2.78b 13.34 ± 2.77b 14.28 ± 3.82b
Range (15.31–23.74) (16.26–21.93) (9.25–16.69) (10.36–18.21) (9.57–19.02)
Change% - 0 -32.62 -30.48 -25.59
MDA(nmol/g)      
Mean ± SD 235.18 ± 16.32a 238.29 ± 18.23a 250.98 ± 12.06a 250.23 ± 13.03a 244.19 ± 13.45a
Range (210.72–256.47) (218.99–269.02) (234.51–267.97) (237.65–276.24) (221.17–257.91)
Change% - 1.32 6.72 6.40 3.83
  1. All parameters are expressed in mg/g tissue unless otherwise stated.
  2. For each parameter similar characters denote insignificance between groups.
  3. The mean difference is significant at p < 0.05.