Table 5 Statistical significance of hepatic lipid profile and malondialdehyde concentration in diabetic-hypercholesterolemic rats treated with bezafibrate, quinazolinone and halogenated derivatives

Total lipids

Mean ± SD

74.76 ± 7.34^a

65.00 ± 7.37^a

71.37 ± 6.01^a

65.93 ± 11.54^a

66.12 ± 9.47^a

Range

(65.88–84.71)

(54.90–76.47)

(62.16–77.65)

(45.49–81.57)

(48.92–78.43)

Change%

-

-13.06

-4.53

-11.81

-11.56

Triacylglycerol

Mean ± SD

12.10 ± 3.37^a

9.90 ± 1.08^a

11.90 ± 4.38^a

12.03 ± 5.07^a

11.80 ± 4.82^a

Range

(8.87–17.30)

(8.38–11.30)

(7.48–16.61)

(6.09–18.78)

(6.23–17.30)

Change%

-

-18.18

-1.65

-0.58

-2.48

Total cholesterol

Mean ± SD

26.53 ± 4.93^a

26.58 ± 3.37^a

23.87 ± 3.58^a

25.62 ± 2.94^a

26.57 ± 2.88^a

Range

(20.05–34.15)

(21.14–31.71)

(18.79–28.86)

(23.58–32.52)

(22.08–30.08)

Change%

-

0.19

-10.03

-3.43

0.15

Free cholesterol

Mean ± SD

7.34 ± 2.45^a

7.49 ± 1.93^a

12.15 ± 2.42^b

12.40 ± 3.17^b

12.29 ± 2.59^b

Range

(4.04–10.41)

(5.69–11.32)

(8.29–16.03)

(8.85–18.31)

(8.98–14.80)

Change%

-

2.04

65.53

68.94

67.44

Cholesterol ester

Mean ± SD

19.19 ± 2.61^a

19.19 ± 1.95^a

12.93 ± 2.78^b

13.34 ± 2.77^b

14.28 ± 3.82^b

Range

(15.31–23.74)

(16.26–21.93)

(9.25–16.69)

(10.36–18.21)

(9.57–19.02)

Change%

-

0

-32.62

-30.48

-25.59

MDA(nmol/g)

Mean ± SD

235.18 ± 16.32^a

238.29 ± 18.23^a

250.98 ± 12.06^a

250.23 ± 13.03^a

244.19 ± 13.45^a

Range

(210.72–256.47)

(218.99–269.02)

(234.51–267.97)

(237.65–276.24)

(221.17–257.91)

Change%

-

1.32

6.72

6.40

3.83