Lipids in Health and Disease

Table 3 Kinetic parameters of LDL, LDL + HDL₂ and LDL + HDL₃ oxidation in 59 healthy subjects.

From: HDL enhances oxidation of LDL in vitro in both men and women

	Women	Men	All
LDL
Lag time (min)	60.9 ± 7.9	59.3 ± 6.9	60.2 ± 7.4
Rate (μmol/l/min)^a	0.509 ± 0.067	0.502 ± 0.067	0.506 ± 0.066
Max (nmol/mg)^b	541 ± 41	537 ± 51	539 ± 45
LDL + HDL ₂
Lag time (min)	56.0 ± 5.7***	56.0 ± 6.7***	56.0 ± 6.1***
Rate (μmol/l/min)^a	0.687 ± 0.062***	0.654 ± 0.084***	0.671 ± 0.073***
Max (nmol/mg)^b	774 ± 40***	745 ± 71***	762 ± 56***
LDL + HDL ₃
Lag time (min)	55.8 ± 5.4***	54.8 ± 5.4***	55.3 ± 5.4***
Rate (μmol/l/min)^a	0.616 ± 0.064***	0.607 ± 0.070***	0.612 ± 0.066***
Max (nmol/mg)^b	687 ± 40***	674 ± 60***	681 ± 50***

Values are mean ± SD. ^a Rate means maximal formation rate of conjugated dienes during oxidation. Calculation of the diene concentration is based on ε = 29500 of the conjugated dienes ^b Max is the maximal amount of dienes produced per mg of LDL protein. *** p < 0.001 in comparison with LDL alone in Wilcoxon's matched pairs test.

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ISSN: 1476-511X

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