Figure 5
From: L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin
Effect of chelating agents on ATX's LPLD activity The LPLD activity of ATX was compared in the presence of 0.5 mM phenanthroline A (phenA), 5 mM EDTA, or 10 mM L-histidine. The effect of adding Zn++ or Ca++ was compared for each chelating agent. Results are expressed as Mean ± SEM. Statistical analysis of results was performed utilizing GraphPad Prism (San Diego, CA). Data that is significantly different from untreated control is shown by: * (p < 0.001), ** (p < 0.05); recovery with metal cations is shown as statistically different from appropriate inhibitor-treated samples: # (p < 0.001).