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Table 2 Biochemical variables of the ROH-RBP4-complex in plasma of controls, patients with CLD and CKD.

From: Isoforms of Retinol binding protein 4 (RBP4) are increased in chronic diseases of the kidney but not of the liver

 

Controls

CLD

CKD

RBP4 (μmoL/L)

2.17 (1.78 – 2.52)

0.97 (0.61 – 1.27) *

3.75 (2.63 – 5.21) * #

ROH (μmoL/L)

1.46 (1.29 – 1.66)

0.94 (0.62 – 1.22) *

1.62 (1.03 – 2.69)#

TTR (μmoL/L)

6.14 (5.22 – 7.01)

1.16 (0.91 – 1.83) *

4.22 (2.66 – 6.02) * #

RBP4/ROH ratio1

1.39 (1.15 – 1.78)

1.04 (0.90 – 1.32) *

1.88 (1.51 – 3.04) * #

RBP4/TTR ratio 2

0.36 (0.30 – 0.41)

0.67 (0.41 – 1.13) *

0.76 (0.61 – 1.49) *

Holo-RBP4 (%)

86.4 (80.7 – 88.8)

85.0 (77.9 – 93.4)

67.0 (54.0 – 76.3) *

Apo-RBP4 (%)

13.6 (11.2 – 19.3)

15.0 (6.3 – 22.0)

32.5 (23.8 – 42.0) *

RBP4-L (%)3

45.0 (24.5 – 73.0)

33.0 (17.5 – 48.0) *

86.5 (39.0 – 143.0) *

RBP4-LL (%)3

0.0 (0.0 – 5.5)

0.0 (0.0 – 6.0)

18.0 (5.75 – 55.8) *

  1. Data are expressed as median with 25th and 75th percentiles. RBP4, retinol binding protein 4; ROH, retinol; TTR, transthyretin.
  2. * = significantly different from controls (p < 0.05). # = significantly different from CLD (p < 0.05).
  3. 1 The RBP4/ROH ratio is the molar ratio of serum RBP4 to serum ROH.
  4. 2 The RBP4/TTR ratio is the molar ratio of serum RBP4 to serum TTR.
  5. 3 The intensity of the non-truncated RBP4 (nRBP4) was set 100% and intensities of RBP4-L and RBP4-LL were expressed in % of nRBP4.
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Lipids in Health and Disease

ISSN: 1476-511X