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Table 2 Biochemical variables of the ROH-RBP4-complex in plasma of controls, patients with CLD and CKD.

From: Isoforms of Retinol binding protein 4 (RBP4) are increased in chronic diseases of the kidney but not of the liver

  Controls CLD CKD
RBP4 (μmoL/L) 2.17 (1.78 – 2.52) 0.97 (0.61 – 1.27) * 3.75 (2.63 – 5.21) * #
ROH (μmoL/L) 1.46 (1.29 – 1.66) 0.94 (0.62 – 1.22) * 1.62 (1.03 – 2.69)#
TTR (μmoL/L) 6.14 (5.22 – 7.01) 1.16 (0.91 – 1.83) * 4.22 (2.66 – 6.02) * #
RBP4/ROH ratio1 1.39 (1.15 – 1.78) 1.04 (0.90 – 1.32) * 1.88 (1.51 – 3.04) * #
RBP4/TTR ratio 2 0.36 (0.30 – 0.41) 0.67 (0.41 – 1.13) * 0.76 (0.61 – 1.49) *
Holo-RBP4 (%) 86.4 (80.7 – 88.8) 85.0 (77.9 – 93.4) 67.0 (54.0 – 76.3) *
Apo-RBP4 (%) 13.6 (11.2 – 19.3) 15.0 (6.3 – 22.0) 32.5 (23.8 – 42.0) *
RBP4-L (%)3 45.0 (24.5 – 73.0) 33.0 (17.5 – 48.0) * 86.5 (39.0 – 143.0) *
RBP4-LL (%)3 0.0 (0.0 – 5.5) 0.0 (0.0 – 6.0) 18.0 (5.75 – 55.8) *
  1. Data are expressed as median with 25th and 75th percentiles. RBP4, retinol binding protein 4; ROH, retinol; TTR, transthyretin.
  2. * = significantly different from controls (p < 0.05). # = significantly different from CLD (p < 0.05).
  3. 1 The RBP4/ROH ratio is the molar ratio of serum RBP4 to serum ROH.
  4. 2 The RBP4/TTR ratio is the molar ratio of serum RBP4 to serum TTR.
  5. 3 The intensity of the non-truncated RBP4 (nRBP4) was set 100% and intensities of RBP4-L and RBP4-LL were expressed in % of nRBP4.