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Table 2 Fatty acid composition in macrophages

From: Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages

Fatty acids

Wild-type

(% of total lipid)

ALDP-deficient

(% of total lipid)

C14:0

1.08 ± 0.21

1.18 ± 0.26

C16:0

21.27 ± 0.96

20.77 ± 0.62

C16:1n-7

2.66 ± 0.24

2.82 ± 0.56

C18:0

14.37 ± 0.47

14.65 ± 1.19

C18:1n-9

9.45 ± 0.80

9.74 ± 0.61

C18:2n-6

11.65 ± 0.27

12.52 ± 0.60**

C18:3n-3

0.27 ± 0.09

0.26 ± 0.06

C20:0

0.27 ± 0.13

0.32 ± 0.11

C20:3n-6

1.37 ± 0.16

1.40 ± 0.14

C20:4n-6

9.82 ± 0.35

9.31 ± 0.52

C20:5n-3

0.34 ± 0.05

0.34 ± 0.06

C22:0

0.40 ± 0.04

0.34 ± 0.04**

C22:4n-6

2.68 ± 0.13

2.54 ± 0.18

C22:5n-3

2.67 ± 0.30

2.45 ± 0.18

C24:0

0.59 ± 0.05

0.69 ± 0.06**

C22:6n-3

4.44 ± 0.40

4.16 ± 0.27

SFA

37.98 ± 1.18

37.94 ± 0.91

n-6 PUFA

25.52 ± 0.69

25.77 ± 0.74

n-3 PUFA

7.73 ± 0.51

7.21 ± 0.38

n-3/n-6

0.30 ± 0.02

0.28 ± 0.01*

n-3/AA

0.79 ± 0.04

0.78 ± 0.06

  1. Data represents mean ± SD, n = 8. ALDP, adrenoleukodystrophy protein; SFA, saturated fatty acid; PUFA, polyunsaturated fatty acid; AA, arachidonic acid. *P < 0.05, **P < 0.01 for comparison with wild-type.