Table 2 Relative gene expression [HF vs. ST] – microarray data
From: Angiogenesis in the New Zealand obese mouse model fed with high fat diet
Inslulin signaling | Proangiogenic cytokines | Adhesion molecules | |||
|---|---|---|---|---|---|
↑ Igf1r | 1,41 | ↑ Vegfa | 9,19 ‡ | ↑ Itga5 | 4,92 |
↓ Irs1 | -1,62 | ↑ Egf | 1,87 | ↑ Itga6 | 1,62 |
↓ Pik3r1 | -1,62 | ↑ Fgf1 | 2,00 | ↑ Itgam | 4,59 |
↓ Pik3r2 | -1,41 | ↑ Fgf18 | 3,48 | ↑ Itgb2 | 2,46 |
↓ Akt2 | -1,52 | ↑ Hbegf | 7,46 | ↑ Itgb1 | 2,14 |
↓ Foxo1 | -1,87 ‡ | ↑ Pdgfa | 3,25 | ↑ Gja1 | 1,62 |
↓ Foxo3a | -1,52 | Proangiogenic receptors | ↓ Pcdhb7 | -2,83 | |
↓ Glut4 | -2,64 ‡ | ↓ Kdr | -8,00 | ↓ Icam1 | -2,00 |
mTor | ↓ Flt1 | -4,29 | ↓ Icam2 | -13,00 | |
↑ Frap1 | 1,41 | ↓ Egfr | -2,83 | ↓ Vcam1 | -6,06 |
↑ Rheb | 1,52 | ↓ Tie1 | -10,56 | ↓ Mcam | -19,70 |
↑ Tsc2 | 1,74 | Fgfr1 | 1,32 | ↓ Pecam1 | -6,96 |
Cell cycle | ↓ Cxcr4 | -2,30 | Extracellular matrix | ||
↓ Ccna2 | -1,62 | Sphingosine 1-P | ↑ Lamb1-1 | 2,83 | |
↓ Cdc2a | -1,41 | ↑ Sphk1 | 1,62 | ↑ Fn1 | 1,41 |
↓ Cdc20 | -1,52 | ↑ Edg1 | 2,46 | ↓ Col18a1 | -3,48 |
↓ Mcm3 | -1,87 | Proang. trans. factors | ↓ Col1a1 | -1,74 | |
↓ Mcm5 | -1,87 | ↓ Hoxd9 | -34,30 | ↓ Col1a2 | -1,62 |
↓ Mcm7 | -1,41 | ↓ Hoxd10 | -7,46 | ↓ Col4a1 | -7,46 |
↓ Orc2l | -2,83 | ↓ HoxA9 | -4,29 | ↓ Col4a2 | -6,50 |
Cell cycle inhibitors | ↓ HoxA10 | -8,00 | ↓ Col4a5 | -2,46 | |
↑ Akt1 | 1,87 | ↑ Jun | 1,62 | ↓ Col6a1 | -2,64 |
↑ p53 | 1,62 | ↑ Fos | 6,06 | ↓ Col6a2 | -3,25 |
↑ p21 | 1,87 | ↑ Egr1 | 2,14 | ↓ Fgg | -3,73 |
↑ p16 | 2,83 | Diff. EC markers | ↓ Sparc | -1,41 | |
↑ Ywhag | 2,46 | ↓ vWf | -4,29 | ↓ Sparcl1 | -16,00 |
Oxidative stress | ↓ Esam1 | -10,56 | ↓ Smoc2 | -4,59 | |
↑ Hspa1a | 6,50 | ↓ eNos | -2,83 ‡ | MMP's & MMP likes | |
↑ Hspb1 | 2,46 | Apoptosis | ↑ Mmp1a | 2,46 | |
↑ Hmox1 | 2,30 | ↓ Bak1 | -1,87 | ↑ Mmp10 | 9,19 |
↑ Ankrd1 | 6,06 | ↓ Bad | -1,74 | ↑ Mmp14 | 1,87 |
Prostaglandin activity | ↓ Bcl2L11 | -3,03 | ↑ Mmp19 | 2,00 | |
↑ Cox1 | 2,46 | ↓ Casp12 | -1,87 | ↑ Adam8 | 2,14 |
↑ Cox2 | 6,50 | ↓ Casp7 | -1,62 | ↑ Adam17 | 1,41 |
↑ Ptgis | 2,00 | ↓ Prf1 | -4,92 | ↑ Adam19 | 1,87 |
↑ Ptgir | 2,46 | ↓ Gzmb | -5,66 | ↑ Adamts4 | 2,30 |
Plasminogen act. | ↓ Birc2 | -2,00 | ↓ Mmp12 | -1,62 | |
↑ Serpine1 | 7,46 | ↓ Birc5 | -2,00 | ↓ Mmp9 | -1,87 |
↑ Serpinb2 | 29,86 | Integrin related kinase | ↓ Mmp2 | -1,62 | |
↑ Plau | 3,25 | ↑ Rock1 | 1,74 | ↓ Mmp23 | -2,14 |
↑ Plaur | 4,00 | Rock2 | 1,23 | ↓ Adamts15 | -7,46 |
↑ Ilk | 1,41 | ↑ Rac1 | 1,41 | Colour explanation: | |
↑ Crk | 1,87 | ↑ Pak1 | 1,52 | up-regulation ↑ | |
↑ Rapgef1 | 2,83 |  |  | down-regulation ↓ | |
↑ Rap1b | 2,14 |  |  |  |  |