Effects of cardiovascular lifestyle change on lipoprotein subclass profiles defined by nuclear magnetic resonance spectroscopy

Decewicz, David J; Neatrour, David M; Burke, Amy; Haberkorn, Mary Jane; Patney, Heather L; Vernalis, Marina N; Ellsworth, Darrell L

doi:10.1186/1476-511X-8-26

Lipids in Health and Disease

Table 3 Changes in selected lipoprotein subclass measurements and standard plasma lipid profiles by gender

From: Effects of cardiovascular lifestyle change on lipoprotein subclass profiles defined by nuclear magnetic resonance spectroscopy

		Controls (n = 73)				Participants (n = 73)
Variable	Gender	Baseline	Week 12	Week 52	% change	Baseline	Week 12	Week 52	% change	Between group p value^a
VLDL particles
Large VLDL/chylomicrons	F	5.7 ± 7.7	6.1 ± 7.4	5.0 ± 6.0	-12.4	7.9 ± 7.0	5.9 ± 6.2	8.1 ± 8.5	+3.0	0.62
	M	3.6 ± 4.5	4.4 ± 5.0	4.1 ± 4.9	+14.5	8.4 ± 6.8	3.6 ± 4.1^b	3.7 ± 4.7^b	-55.9	< 0.01
LDL particles
Total LDL particles	F	1364 ± 388	1376 ± 500	1347 ± 475	-1.3	1478 ± 497	1356 ± 460	1388 ± 516	-6.1	0.42
	M	1156 ± 323	1126 ± 302	1163 ± 335	+0.6	1401 ± 463	1234 ± 430^c	1256 ± 385^c	-10.4	0.03
Small LDL particles	F	902 ± 491	914 ± 548	924 ± 534	+2.4	1076 ± 565	1046 ± 485	1048 ± 568	-2.6	0.63
	M	843 ± 382	834 ± 334	857 ± 381	+1.7	1145 ± 393	1006 ± 385^c	972 ± 368^c	-15.1	< 0.01
LDL size	F	20.9 ± 0.9	20.9 ± 0.9	20.8 ± 0.9	-0.4	20.5 ± 0.9	20.4 ± 0.7	20.5 ± 0.8	0.0	0.62
	M	20.6 ± 0.8	20.5 ± 0.7	20.5 ± 0.7	0.0	20.0 ± 0.6	20.1 ± 0.6	20.3 ± 0.6^c	+1.6	< 0.01
HDL particles
Large HDL particles	F	7.4 ± 3.7	7.8 ± 3.5	7.4 ± 3.8	-0.3	5.8 ± 4.1	5.1 ± 2.6^c	5.7 ± 3.1	-2.6	0.83
	M	5.4 ± 3.0	5.7 ± 2.8	5.6 ± 2.9	+3.3	3.5 ± 2.1	3.7 ± 1.4	4.7 ± 2.7^c	+34.9	0.03
HDL size	F	9.0 ± 0.4	9.0 ± 0.4	8.9 ± 0.4	-0.7	8.8 ± 0.3	8.7 ± 0.2	8.8 ± 0.3	+0.4	0.07
	M	8.7 ± 0.4	8.8 ± 0.4	8.7 ± 0.4	0.0	8.5 ± 0.2	8.6 ± 0.2^c	8.6 ± 0.4^c	+1.6	0.03
Lipid profiles
HDL-cholesterol	F	55.9 ± 12.6	57.2 ± 11.8	52.9 ± 13.0	-5.3	49.2 ± 15.5	40.7 ± 10.5^b	45.5 ± 9.3^c	-7.4	0.77
	M	45.9 ± 13.0	47.3 ± 11.7	43.8 ± 12.6	-4.5	38.9 ± 8.1	34.8 ± 6.6^c	40.4 ± 10.6	+3.8	0.03
Tot cholesterol	F	211 ± 35	213 ± 44	208 ± 43	-1.4	206 ± 48	181 ± 42^b	197 ± 43	-4.5	0.42
	M	173 ± 40	173 ± 38	177 ± 44	+2.0	182 ± 45	156 ± 43^b	171 ± 41	-6.4	0.02
Triglycerides	F	164 ± 105	181 ± 193	157 ± 85	-3.9	192 ± 100	188 ± 83	199 ± 117	+3.9	0.54
	M	134 ± 95	139 ± 62	148 ± 94	+9.8	187 ± 100	149 ± 59^c	140 ± 65^c	-24.9	< 0.01

Values are presented as mean ± SD; differences between table values and calculated values are due to rounding; % change = week 0–52. There were 34 women and 39 men in each group, there was no missing data. a: p values resulting from independent samples t-tests (two-tailed) of Baseline to Week 52 changes for female Ornish participants compared to female controls and male Ornish participants compared to male controls, b: values at Week 12 and Week 52 were significantly different from Baseline at p < 0.001 based on repeated measures ANOVA (time point was the within-subjects factor, cohort type and gender within cohorts were the between-subjects factors) using a Bonferroni adjustment for multiple comparisons by time point, group, and gender within group, c: values at Week 12 and Week 52 were significantly different from Baseline at p < 0.05 based on repeated measures ANOVA (time point was the within-subjects factor, cohort type and gender within cohorts were the between-subjects factors) using a Bonferroni adjustment for multiple comparisons by time point, group, and gender within group.

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ISSN: 1476-511X

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