Inhibition of hepatic lipid accumulation by compound 1a in high-fat diet-fed obese mice. Histological analyses of hepatic lipid accumulation. Representative HE-stained liver sections are shown (original magnification 200×). A presents the normal hepatocyte appearance. High fat diet induced hepatocytes necrosis was shown in B. After the treatment of compound 1a, necrosis hepatocytes are reduced, especially in D. Small lipid drops were seen C. There were obvious lipid drops in E. A: low fat diet (normal group); B: high fat diet (model group); C: high fat diet+50 mg·kg-1 compound 1a (low dosage group); D: high fat diet+100 mg·kg-1 compound 1a (high dosage group); E: high fat diet+200 mg·kg-1 Inositol Hexanicotinate (control group).