Figure 1From: Genetic variation in lipid desaturases and its impact on the development of human diseaseFatty acid desaturases in PUFA and eicosanoid biosynthesis. The D6D (Fads2) and D5D (Fads1) enzymes play important roles in the biosynthesis of polyunsaturated fatty acids (PUFA). Moreover, these desaturases lead to the generation of pro-inflammatory (via n-6 PUFA) and anti-inflammatory (via n-3 PUFA) eicosanoids.Back to article page