Skip to main content

Table 1 ApoE isoform amino acid differences and resulting chemical and physiological changes (according to Mahley and Rall [2], Minihane et al. [7])

From: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

Isoform Amino acid 112 Amino acid 158 Relative charge Lipoprotein preference LDL receptor binding affinity
apoE2 cysteine cysteine 0 HDL low
apoE3 cysteine arginine +1 HDL high
apoE4 arginine arginine +2 VLDL, chylomicrons high
  1. HDL: high density lipoprotein, VLDL: very low density lipoprotein