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Table 1 Comparison between the main fatty acid composition of freshly obtained human lymphocytes and lymphoblastoid cell lines transfected with the empty vector.

From: The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: Differences between normal controls and children with the Zellweger syndrome

 

Fresh

EBV immortalized

14:0

0.49

2.06

16:0

19.59

21.06

16:1ω9

0.28

2.21

16:1ω7

0.28

1.27

18:0

19.72

15.66

18:1ω9

15.30

19.29

18:1ω7

1.68

7.29

18:2ω6

7.49

2.75

18:3ω6

0.03

0.09

18:3ω3

0.09

0.06

20:0

1.00

0.25

20:1ω9

0.64

1.45

20:3ω9

0.10

0.74

20:3ω6

1.65

3.21

20:4ω6

19.79

7.06

20:5ω3

0.31

0.58

22:4ω6

2.13

1.23

22:5ω6

0.37

0.31

22:5ω3

1.34

4.20

22:6ω3

2.01

4.46

ω6/ω3

7.72

1.41

22:6ω3/22:5ω3

1.50

1.06

22:5ω6/22:4ω6

0.17

0.26

20:4ω6/20:3ω6

11.99

2.20

22:4ω6/20:4ω6

0.11

0.17

  1. This table compares the main fatty acid composition (mol%) of freshly processed human lymphocytes with that of lymphoblastoid cell lines immortalized with the Epstein-Barr virus and transfected with the empty plasmid pIRES2EGFP (mean). Note the very different arachidonic acid content of fresh and treated cells. In contrast, the ω3 PUFAs are higher and the 22:6ω3/22:5ω3 ratio is comparatively lower in the processed cells. Also, note the higher values of ω9 and ω7 fatty acids in the EBV-treated cells.
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Lipids in Health and Disease

ISSN: 1476-511X