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Table 8 Effect of FVBM, F18 bioactive compound and atorvastatin on the ratios of plasma HDL-C/TC, HDL-C/LDL-C, TC/HDL-C and LDL-C/HDL-C in Triton WR-1339 induced hyperlipidemic rats after 18 hours of the treatment

From: Bioactivity guided fractionation and hypolipidemic property of a novel HMG-CoA reductase inhibitor from Ficus virens Ait

Group/Ratio HDL-C/TC HDL-C/LDL-C TC/HDL-C LDL-C/ HDL-C
NC 0.3625 ± .025* 0.7746 ± 0.088 2.758 ± 0.105 1.2909 ± 0.0576
HLC 0.0615 ± 0.003* 0.0795 ± 0.0074 16.244 ± 0.76 12.5727 ± 0.65
(−5.89 f)a (−9.74 f)a (+5.88 f)a (+9.73 f)a
FVT-1 0.2110 ± 0.0048* 0.3281 ± 0.0075 4.737 ± 0.094 3.0473 ± 0.086
(+4.13 f)a (−3.43 f)a (−4.12 f)a
(+3.43 f)a
FVT-2 0.3525 ± 0.0071* 0.7518 ± 0.074 2.836 ± 0.115 1.3299 ± 0.034
(+9.45 f)a (−5.72 f)a (−9.45 f)a
(+5.73 f)a
CT 0.3337 ± 0.0042* 0.6518 ± 0.015 2.996 ± 0.081 1.5340 ± 0.0691
(+8.19 f)a (−5.42 f)a (−8.21 f)a
(+5.42 f)a
AT 0.3630 ± 0.0036* 0.7497 ± 0.028 2.754 ± 0.129 1.3338 ± 0.064
(+9.43 f)a (−5.89 f)a (−9.42 f)a
(+5.90 f)a
  1. For the calculation of ratios, data is taken from Tables 5 and 6.
  2. *Values are mean (mg/dl) ± SD from plasma of 5 rats in each group.
  3. NC, normal control; HLC, triton induced hyperlipidemic control; FVT-1, fed 50 mg FVBM extract/rat; FVT-2, fed 100 mg FVBM extract/rat; CT, fed 1 mg F18 bioactive compound/rat and AT, given 1 mg atorvastatin/rat once.
  4. ‘f’ stands for fold.
  5. Significantly different from NC at ap < 0.001.
  6. Significantly different from HLC at ap < 0.001.