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Figure 4 | Lipids in Health and Disease

Figure 4

From: Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet

Figure 4

Effects of castration and testosterone replacement on liver SREBP2 (A), LXRα (B), HMGCR (C), LDLR (D), CYP7A1 (E), and PCSK9 (F) mRNA expression in pigs fed a high-fat and high-cholesterol diet. SREBP2, sterol regulatory element binding protein 2; LXRα, liver X receptor alpha; HMGCR, 3-hydroxy-3-methylgutaryl coenzyme A reductase; LDLR, low-density lipoprotein receptor; CYP7A1, cholesterol 7α-hydroxylase; PCSK9, proprotein convertase subtilisin/kexin type 9. Data are presented as mean ± SEM; n = 6 pigs per group. *P < 0.05, significant differences compared to the CM + HFC group determined by ANOVA (Tukey’s test).

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Lipids in Health and Disease

ISSN: 1476-511X