Chronic mild stress decreased cholesterol levels. The levels of cholesterol were significantly decreased by CMS in the medial prefrontal cortex (a) but not in the hippocampus (b). Data are expressed as mean ± SEM (n = 8 per group). Differences between control and CMS were assessed using Tukey’s post hoc test. **P < 0.01 compared with control rats. CMS, chronic mild stress.