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Table 2 Change from baseline to 24 weeks in glucose parameters

From: A randomized, double-blind, placebo-controlled study of the effect of ezetimibe on glucose metabolism in subjects with type 2 diabetes mellitus and hypercholesterolemia

  

Baseline

Week 24

Change

 

Treatment (n)

Mean (SE)

Mean (SE)

Mean (SE)

LS Mean (95% CI)

P-value

HbA1c (%)

Ezetimibe (n = 69)

6.94 (0.07)

7.14 (0.10)

0.20 (0.06)

0.22 (0.11, 0.34)

<0.001

Placebo (n = 75)

6.96 (0.06)

7.09 (0.07)

0.13 (0.05

0.14 (0.03, 0.25)

0.015

Ezetimibe vs Placebo

 

Difference in LS mean (95% CI)

0.08 (−0.07, 0.23)

0.281

Glyocalbumin (%)

Ezetimibe (n = 69)

17.16 (0.26)

17.14 (0.30)

−0.02 (0.17)

−0.02 (−0.37, 0.34)

0.919

Placebo (n = 75)

17.21 (0.27)

17.20 (0.29)

−0.01 (0.17)

−0.02 (−0.37, 0.33)

0.918

Ezetimibe vs Placebo

 

Difference in LS mean (95% CI)

0.00 (−0.47, 0.47)

1.000

Fasting plasma glucose (mg/dL)

Ezetimibe (n = 69)

124.7 (2.6)

128.0 (2.8)

3.3 (3.0)

6.6 (1.1, 12.1)

0.019

Placebo (n = 75)

126.7 (2.0)

135.4 (2.9)

8.7 (2.5)

11.4 (6.1, 16.7)

<0.001

Ezetimibe vs Placebo

 

Difference in LS mean (95% CI)

−4.8 (−12.1, 2.5)

0.194