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Figure 3 | Lipids in Health and Disease

Figure 3

From: Saturated fatty acids in human visceral adipose tissue are associated with increased 11- β-hydroxysteroid-dehydrogenase type 1 expression

Figure 3

This schematic picture presents a hypothetical link between SFAs and HSD11B1 expression. SFAs may function as signalling molecules and alter transcription of HSD11B1. The increased HSD11B1 expression in VAT is associated with an increased protein expression of the enzyme which results in an elevated conversion of cortisone to cortisol. Cortisol binds to the glucocorticoid receptor (GR) which regulates transcription which results in VAT adipogenesis and increased hepatic lipid accumulation due to induced AT lipolysis. It should be noted that the suggested mechanism is simplified and a model extracted from the observed associations and ought to be confirmed before considered valid.

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Lipids in Health and Disease

ISSN: 1476-511X