Table 3 Multivariate associations of the SNPs in APOC4 and LPA gene with the risk of premature CAD
Type | Controls (n = 297) | Cases (n = 224) | OR (95 % CI)a | P-valuea |
|---|---|---|---|---|
No. (%) | No. (%) | |||
APOC4 rs1132899 | ||||
T | 195 (32.8) | 132 (29.5) | 1.00 | - |
C | 399 (67.2) | 316 (70.5) | 1.50 (1.05–2.14) | 0.027 b |
TT | 30 (10.1) | 15 (6.7) | 1.00 | - |
CT | 135 (45.5) | 102 (45.5) | 2.15 (0.89–5.20) | 0.089 |
CC | 132 (44.4) | 107 (47.8) | 2.84 (1.17–6.92) | 0.022 |
APOC4 rs5167 | ||||
T | 286 (48.1) | 217 (48.4) | 1.00 | - |
G | 308 (51.9) | 231 (51.6) | 0.75 (0.54–1.03) | 0.078 |
TT | 66 (22.2) | 47 (21.0) | 1.00 | - |
GT | 154 (51.9) | 123 (54.9) | 1.35 (0.78–2.35) | 0.289 |
GG | 77 (25.9) | 54 (24.1) | 1.79 (0.94–3.43) | 0.078 |
LPA rs1801693 | ||||
T | 327 (55.1) | 249 (55.6) | 1.00 | - |
C | 267 (44.9) | 199 (44.4) | 0.94 (0.70–1.28) | 0.707 |
TT | 89 (30.0) | 71 (31.7) | 1.00 | - |
CT | 149 (50.2) | 107 (47.8) | 1.00 (0.61–1.65) | 0.997 |
CC | 59 (19.8) | 46 (20.5) | 1.14 (0.62–2.10) | 0.681 |
LPA rs7765781 | ||||
C | 213 (35.9) | 159 (35.5) | 1.00 | - |
G | 381 (64.1) | 289 (64.5) | 1.04 (0.76–1.43) | 0.807 |
CC | 39 (13.1) | 28 (12.5) | 1.00 | - |
CG | 135 (45.5) | 103 (46.0) | 1.16 (0.59–2.25) | 0.674 |
GG | 123 (41.4) | 93 (41.5) | 1.13 (0.58–2.22) | 0.724 |