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Table 2 Dietary effects on liver weight, plasma and hepatic lipid content

From: Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice

Parameter

8 weeks

12 weeks

Control

HFD ED

HFD CO

Control

HFD ED

HFD CO

n

9

12

12

10

9

10

Liver (% Bw)

4.4 ± 0.5

4.5 ± 0.3

4.2 ± 0.2

4.6 ± 0.1ab

4.3 ± 0.1a

4.8 ± 0.1b

Hepatic total lipid (mg/g dry liver weight)a

4.6 ± 0.3a

3.9 ± 0.2a

6.9 ± 0.4b

5.2 ± 0.5ab

4.7 ± 0.3a

6.5 ± 0.5b

Plasma triglycerides (mmole/L)

0.9 ± 0.1ab

1.1 ± 0.1a

0.7 ± 0.0b

1.2 ± 0.1

1.0 ± 0.1

1.0 ± 0.1

Hepatic total cholesterol (mg/g dry liver weight)

5.0 ± 0.2a

6.2 ± 0.4b

6.0 ± 0.1b

4.4 ± 0.1a

6.4 ± 0.2b

6.4 ± 0.2b

Plasma total cholesterol (mmole/L)

5.6 ± 0.9

5.5 ± 0.8

5.4 ± 0.9

6.3 ± 0.3a

6.0 ± 0.3a

9.2 ± 0.5b

  1. Data are shown as mean ± SEM; different letters show significant differences tested by ANOVA followed by Tukey’s multiple comparison test
  2. aLipid measurements n = 7, 8, 8 for Control, HFD-EPA/DHA and HFD-corn oil, respectively. High fat diet (HFD)- EPA/DHA (ED) and HFD-corn oil (CO)