| |
8 week
|
12 week
|
|---|
|
Neutral Lipids
|
Control
|
HFD ED
|
HFD CO
|
Control
|
HFD ED
|
HFD CO
|
|
Sum SFA
|
15.5 ± 1.3
|
12.3 ± 2.0
|
26.3 ± 1.7
|
20.6 ± 2.5
|
15.6 ± 1.8
|
23.6 ± 1.3
|
|
C16:0
|
13.5 ± 1.2a
|
10.2 ± 1.5a
|
23.9 ± 1.6b
|
18.2 ± 2.3ab
|
13.8 ± 1.6a
|
21.2 ± 1.2b
|
|
C18:0
|
2.1 ± 0.1
|
2.1 ± 0.5
|
2.4 ± 0.2
|
2.3 ± 0.2ab
|
1.9 ± 0.2a
|
2.4 ± 0.1b
|
|
Sum MUFA
|
28.0 ± 3.3
|
11.0 ± 2.8
|
44.3 ± 3.5
|
37.1 ± 6.3
|
19.9 ± 3.5
|
49.6 ± 4.0
|
|
C16:1n-7
|
4.1 ± 0.5a
|
2.2 ± 0.6b
|
1.8 ± 0.2b
|
5.5 ± 0.9a
|
4.2 ± 0.7a
|
9.6 ± 0.7b
|
|
C18:1n-9
|
19.4 ± 2.1a
|
7.9 ± 1.9b
|
33.9 ± 2.6c
|
25.1 ± 4.4ab
|
13.9 ± 2.4a
|
31.7 ± 2.6b
|
|
C18:1n-7
|
4.5 ± 0.7a
|
0.9 ± 0.3b
|
8.5 ± 0.8c
|
6.5 ± 1.1a
|
1.7 ± 0.4b
|
8.2 ± 0.7a
|
|
Sum n-6 PUFA
|
9.4 ± 0.4
|
7.7 ± 1.3
|
14.9 ± 0.8
|
8.9 ± 1.0
|
7.9 ± 0.5
|
17.1 ± 0.9
|
|
C18:2n-6
|
6.9 ± 0.3a
|
6.8 ± 1.0a
|
14.9 ± 0.8b
|
7.2 ± 0.7a
|
7.9 ± 0.5a
|
14.9 ± 0.7b
|
|
C20:4n-6
|
2.4 ± 0.1a
|
0.9 ± 0.3b
|
0.0 ± 0.0c
|
1.7 ± 0.2a
|
0.0 ± 0.0b
|
2.2 ± 0.3a
|
|
Sum n-3 PUFA
|
0.0 ± 0.0
|
9.2 ± 1.5
|
0.0 ± 0.0
|
0.3 ± 0.0
|
11.5 ± 1.3
|
0.0 ± 0.0
|
|
C20:5n-3 (EPA)
|
0.0 ± 0.0a
|
1.6 ± 0.3b
|
0.0 ± 0.0a
|
0.0 ± 0.0a
|
2.3 ± 0.3b
|
0.0 ± 0.0a
|
|
C22:6n-3 (DHA)
|
0.0 ± 0.0a
|
7.6 ± 1.2b
|
0.0 ± 0.0a
|
0.3 ± 0.0a
|
9.3 ± 1.0b
|
0.0 ± 0.0a
|
|
Phospholipids
| | | | | | |
|
Sum SFA
|
19.4 ± 0.7
|
23.0 ± 1.2
|
17.1 ± 0.5
|
20.5 ± 0.5
|
21.7 ± 1.2
|
17.8 ± 1.0
|
|
C16:0
|
11.6 ± 0.4a
|
15.3 ± 0.7b
|
10.7 ± 0.3a
|
12.6 ± 0.3ab
|
14.7 ± 0.8b
|
11.2 ± 0.6a
|
|
C18:0
|
7.8 ± 0.3a
|
7.7 ± 0.5a
|
6.4 ± 0.2b
|
8.0 ± 0.2a
|
7.0 ± 0.4ab
|
6.6 ± 0.4b
|
|
Sum MUFA
|
7.2 ± 0.2
|
6.5 ± 0.4
|
6.40.2
|
7.5 ± 0.1
|
6.2 ± 0.3
|
6.3 ± 0.2
|
|
C16:1n-7
|
1.0 ± 0.0
|
0.9 ± 0.1
|
1.1 ± 0.1
|
0.9 ± 0.0
|
0.9 ± 0.1
|
1.0 ± 0.0
|
|
C18:1n-9
|
6.2 ± 0.2a
|
5.6 ± 0.3ab
|
5.3 ± 0.1b
|
6.6 ± 0.1a
|
5.4 ± 0.2b
|
5.3 ± 0.2b
|
|
Sum n-6 PUFA
|
21.2 ± 0.8
|
11.7 ± 1.1
|
19.8 ± 1.4
|
19.6 ± 0.8
|
11.7 ± 0.8
|
20.8 ± 0.9
|
|
C18:2n-6
|
6.0 ± 0.3
|
6.6 ± 1.0
|
6.2 ± 0.9
|
5.4 ± 0.2a
|
6.6 ± 0.5ab
|
7.7 ± 0.4b
|
|
C20:3n-6
|
1.2 ± 0.1a
|
0.4 ± 0.0b
|
2.0 ± 0.1c
|
1.2 ± 0.1a
|
0.6 ± 0.0b
|
1.7 ± 0.1c
|
|
C20:4n-6
|
13.9 ± 0.4a
|
4.7 ± 0.1b
|
11.6 ± 0.4c
|
13.0 ± 0.5a
|
4.6 ± 0.3b
|
11.3 ± 0.4c
|
|
Sum n-3 PUFA
|
3.5 ± 0.1
|
13.2 ± 2.0
|
2.8 ± 0.1
|
2.7 ± 0.2
|
12.4 ± 0.8
|
2.2 ± 0.1
|
|
C20:5n-3 (EPA)
|
0.0 ± 0.0a
|
0.4 ± 0.0b
|
0.0 ± 0.0a
|
0.0 ± 0.0a
|
0.4 ± 0.0b
|
0.0 ± 0.0a
|
|
C22:6n-3 (DHA)
|
3.5 ± 0.1a
|
12.7 ± 2.0b
|
2.8 ± 0.1a
|
2.7 ± 0.2a
|
12.4 ± 0.8b
|
2.2 ± 0.1a
|
- Data are presented as mg/g dry liver weight and shown as mean±SEM. Different letter shows significant differences tested by ANOVA followed by Tukey's multiple comparison test
- Liver fatty acid profiles n = 7, 8, 8 for Control, HFD ED and HFD CO, respectively. High fat diet (HFD)- EPA/DHA (ED) and HFD-corn oil (CO)
