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Table 3 Liver fatty acids profiles

From: Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice

  8 week 12 week
Neutral Lipids Control HFD ED HFD CO Control HFD ED HFD CO
Sum SFA 15.5 ± 1.3 12.3 ± 2.0 26.3 ± 1.7 20.6 ± 2.5 15.6 ± 1.8 23.6 ± 1.3
C16:0 13.5 ± 1.2a 10.2 ± 1.5a 23.9 ± 1.6b 18.2 ± 2.3ab 13.8 ± 1.6a 21.2 ± 1.2b
C18:0 2.1 ± 0.1 2.1 ± 0.5 2.4 ± 0.2 2.3 ± 0.2ab 1.9 ± 0.2a 2.4 ± 0.1b
Sum MUFA 28.0 ± 3.3 11.0 ± 2.8 44.3 ± 3.5 37.1 ± 6.3 19.9 ± 3.5 49.6 ± 4.0
C16:1n-7 4.1 ± 0.5a 2.2 ± 0.6b 1.8 ± 0.2b 5.5 ± 0.9a 4.2 ± 0.7a 9.6 ± 0.7b
C18:1n-9 19.4 ± 2.1a 7.9 ± 1.9b 33.9 ± 2.6c 25.1 ± 4.4ab 13.9 ± 2.4a 31.7 ± 2.6b
C18:1n-7 4.5 ± 0.7a 0.9 ± 0.3b 8.5 ± 0.8c 6.5 ± 1.1a 1.7 ± 0.4b 8.2 ± 0.7a
Sum n-6 PUFA 9.4 ± 0.4 7.7 ± 1.3 14.9 ± 0.8 8.9 ± 1.0 7.9 ± 0.5 17.1 ± 0.9
C18:2n-6 6.9 ± 0.3a 6.8 ± 1.0a 14.9 ± 0.8b 7.2 ± 0.7a 7.9 ± 0.5a 14.9 ± 0.7b
C20:4n-6 2.4 ± 0.1a 0.9 ± 0.3b 0.0 ± 0.0c 1.7 ± 0.2a 0.0 ± 0.0b 2.2 ± 0.3a
Sum n-3 PUFA 0.0 ± 0.0 9.2 ± 1.5 0.0 ± 0.0 0.3 ± 0.0 11.5 ± 1.3 0.0 ± 0.0
C20:5n-3 (EPA) 0.0 ± 0.0a 1.6 ± 0.3b 0.0 ± 0.0a 0.0 ± 0.0a 2.3 ± 0.3b 0.0 ± 0.0a
C22:6n-3 (DHA) 0.0 ± 0.0a 7.6 ± 1.2b 0.0 ± 0.0a 0.3 ± 0.0a 9.3 ± 1.0b 0.0 ± 0.0a
Phospholipids       
Sum SFA 19.4 ± 0.7 23.0 ± 1.2 17.1 ± 0.5 20.5 ± 0.5 21.7 ± 1.2 17.8 ± 1.0
C16:0 11.6 ± 0.4a 15.3 ± 0.7b 10.7 ± 0.3a 12.6 ± 0.3ab 14.7 ± 0.8b 11.2 ± 0.6a
C18:0 7.8 ± 0.3a 7.7 ± 0.5a 6.4 ± 0.2b 8.0 ± 0.2a 7.0 ± 0.4ab 6.6 ± 0.4b
Sum MUFA 7.2 ± 0.2 6.5 ± 0.4 6.40.2 7.5 ± 0.1 6.2 ± 0.3 6.3 ± 0.2
C16:1n-7 1.0 ± 0.0 0.9 ± 0.1 1.1 ± 0.1 0.9 ± 0.0 0.9 ± 0.1 1.0 ± 0.0
C18:1n-9 6.2 ± 0.2a 5.6 ± 0.3ab 5.3 ± 0.1b 6.6 ± 0.1a 5.4 ± 0.2b 5.3 ± 0.2b
Sum n-6 PUFA 21.2 ± 0.8 11.7 ± 1.1 19.8 ± 1.4 19.6 ± 0.8 11.7 ± 0.8 20.8 ± 0.9
C18:2n-6 6.0 ± 0.3 6.6 ± 1.0 6.2 ± 0.9 5.4 ± 0.2a 6.6 ± 0.5ab 7.7 ± 0.4b
C20:3n-6 1.2 ± 0.1a 0.4 ± 0.0b 2.0 ± 0.1c 1.2 ± 0.1a 0.6 ± 0.0b 1.7 ± 0.1c
C20:4n-6 13.9 ± 0.4a 4.7 ± 0.1b 11.6 ± 0.4c 13.0 ± 0.5a 4.6 ± 0.3b 11.3 ± 0.4c
Sum n-3 PUFA 3.5 ± 0.1 13.2 ± 2.0 2.8 ± 0.1 2.7 ± 0.2 12.4 ± 0.8 2.2 ± 0.1
C20:5n-3 (EPA) 0.0 ± 0.0a 0.4 ± 0.0b 0.0 ± 0.0a 0.0 ± 0.0a 0.4 ± 0.0b 0.0 ± 0.0a
C22:6n-3 (DHA) 3.5 ± 0.1a 12.7 ± 2.0b 2.8 ± 0.1a 2.7 ± 0.2a 12.4 ± 0.8b 2.2 ± 0.1a
  1. Data are presented as mg/g dry liver weight and shown as mean±SEM. Different letter shows significant differences tested by ANOVA followed by Tukey's multiple comparison test
  2. Liver fatty acid profiles n = 7, 8, 8 for Control, HFD ED and HFD CO, respectively. High fat diet (HFD)- EPA/DHA (ED) and HFD-corn oil (CO)