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Table 1 Phospholipid fatty acid profile of control and ALA-treated BT-474 cells. Results are presented as molar % of total fatty acids. N = 6

From: α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways

  Control ALA
14:0 2.03 ± 0.62 1.27 ± 1.08
16:0 28.95 ± 4.94 27.16 ± 4.68
18:0 18.11 ± 3.14 17.95 ± 2.62
20:0 0.94 ± 0.21 0.56 ± 0.13
22:0 0.10 ± 0.03a 1.14 ± 0.10b
16:1 n-7 6.97 ± 2.86 6.24 ± 3.55
18:1n-9 16.45 ± 1.03 11.74 ± 1.62
18:1n-7 4.36 ± 0.18a 2.68 ± 0.34b
20:1n-9 0.32 ± 0.08 0.05 ± 0.02
22:1n-9 1.35 ± 0.70a 0.53 ± 0.20b
18:2n-6 4.68 ± 0.86 3.11 ± 0.42
18:3n-6 1.95 ± 0.92 1.15 ± 0.29
20:2n-6 0.35 ± 0.05a 0.18 ± 0.03b
20:4n-6 6.34 ± 0.63a 2.83 ± 0.79b
22:4n-6 0.38 ± 0.05a 0.14 ± 0.02b
22:5n-6 0.08 ± 0.04 0.04 ± 0.01
18:3n-3 0.39 ± 0.15a 19.60 ± 3.60b
20:3n-3 2.64 ± 0.22a 1.09 ± 0.10b
20:5n-3 1.29 ± 0.81 1.14 ± 0.19
22:5n-3 1.18 ± 0.06 0.84 ± 0.17
22:6n-3 1.15 ± 0.12a 0.55 ± 0.14b
n-6:n-3 2.09 ± 0.08a 0.34 ± 0.07b
  1. *values with different superscripts in the same row are significantly different by unpaired T-test