Table 6 Interactions of genotypes and low folate with hypertriglyceridemia
Genotype | Folate statusa | High TAGb | Low TAGb | OR (95Â % Cl) | Pc | Trend test | Pc |
|---|---|---|---|---|---|---|---|
MTHFR C677T | Â | ||||||
 CC | High FA | 30 (20.8) | 54 (19.2) | Reference |  | 0.10 (0.02) | 0.049 |
 CT + TT | High FA | 62 (43.1) | 160 (56.9) | 0.66 (0.38-1.16) | 0.153 | ||
 CC | Low FA | 11 (7.6) | 13 (4.6) | 1.44 (0.43-4.81) | 0.555 | ||
 CT + TT | Low FA | 41 (28.5) | 54 (19.2) | 1.44 (0.70-2.94) | 0.325 | ||
MTHFR A1298C | Â | ||||||
 AA | High FA | 60 (41.7) | 151 (53.7) | Reference |  | 0.14 (0.02) | 0.004 |
 AC + CC | High FA | 32 (22.2) | 63 (22.4) | 1.27 (0.74-2.17) | 0.388 | ||
 AA | Low FA | 38 (26.4) | 50 (17.8) | 2.23 (1.27-3.91) | 0.005 | ||
 AC + CC | Low FA | 14 (9.7) | 17 (6.0) | 2.51 (1.07-5.89) | 0.035 | ||
MTR A2756G | Â | ||||||
 AA | High FA | 76 (52.8) | 180 (64.1) | Reference |  | 0.13 (0.02) | 0.007 |
 AG + GG | High FA | 16 (11.1) | 34 (12.1) | 1.09 (0.55-2.16) | 0.802 | ||
 AA | Low FA | 41 (28.5) | 51 (18.1) | 2.05 (1.20-3.52) | 0.009 | ||
 AG + GG | Low FA | 11 (7.6) | 16 (5.7) | 1.92 (0.82-4.53) | 0.134 | ||
MTRR A66G | Â | ||||||
 AA | High FA | 24 (16.7) | 78 (27.8) | Reference |  | 0.14 (0.02) | 0.005 |
 AG + GG | High FA | 68 (47.2) | 136 (48.4) | 1.47 (0.84-2.57) | 0.173 | ||
 AA | Low FA | 17 (11.8) | 18 (6.4) | 3.39 (1.31-8.79) | 0.012 | ||
 AG + GG | Low FA | 35 (24.3) | 49 (17.4) | 2.51 (1.21-5.19) | 0.013 | ||