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Table 6 Interactions of genotypes and low folate with hypertriglyceridemia

From: Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study

Genotype Folate statusa High TAGb Low TAGb OR (95 % Cl) Pc Trend test Pc
MTHFR C677T  
 CC High FA 30 (20.8) 54 (19.2) Reference   0.10 (0.02) 0.049
 CT + TT High FA 62 (43.1) 160 (56.9) 0.66 (0.38-1.16) 0.153
 CC Low FA 11 (7.6) 13 (4.6) 1.44 (0.43-4.81) 0.555
 CT + TT Low FA 41 (28.5) 54 (19.2) 1.44 (0.70-2.94) 0.325
MTHFR A1298C  
 AA High FA 60 (41.7) 151 (53.7) Reference   0.14 (0.02) 0.004
 AC + CC High FA 32 (22.2) 63 (22.4) 1.27 (0.74-2.17) 0.388
 AA Low FA 38 (26.4) 50 (17.8) 2.23 (1.27-3.91) 0.005
 AC + CC Low FA 14 (9.7) 17 (6.0) 2.51 (1.07-5.89) 0.035
MTR A2756G  
 AA High FA 76 (52.8) 180 (64.1) Reference   0.13 (0.02) 0.007
 AG + GG High FA 16 (11.1) 34 (12.1) 1.09 (0.55-2.16) 0.802
 AA Low FA 41 (28.5) 51 (18.1) 2.05 (1.20-3.52) 0.009
 AG + GG Low FA 11 (7.6) 16 (5.7) 1.92 (0.82-4.53) 0.134
MTRR A66G  
 AA High FA 24 (16.7) 78 (27.8) Reference   0.14 (0.02) 0.005
 AG + GG High FA 68 (47.2) 136 (48.4) 1.47 (0.84-2.57) 0.173
 AA Low FA 17 (11.8) 18 (6.4) 3.39 (1.31-8.79) 0.012
 AG + GG Low FA 35 (24.3) 49 (17.4) 2.51 (1.21-5.19) 0.013
  1. TAG triacylglycerols
  2. aHigh FA: serum folate level ≥ 10 nmol/L, Low FA: serum folate level < 10 nmol/L
  3. bHigh TAG: serum TAG > 1.70 mmol/L; Low TAG: serum TAG ≤ 1.70 mmol/L
  4. cAdjusted for sex, age, clinical centers, height and weight