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Table 4 Interaction between polymorphisms studied with saturated fat intake (≥12 g/d) and total fat (≥83 g/d)

From: Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects

Variables Obesity Cholesterol Triglycerides LDL-C HDL-C
IMC ≥ 30 kg/m2 ≥200 mg/dL ≥150 mg/dL ≥100 mg/dL ≤40 mg/dL
OR (95 % CI); P a
SFA ≥ 12 g/d 3.9 (2.0–7.6); <0.001 1.8 (0.8–4.1); 0.15 1.3 (0.7–2.7); 0.4 1.5 (0.8–2.7); 0.2 1.0 (0.6–1.8); 0.9
Total fat ≥ 83 g/d 3.8 (1.9–7.7); <0.001 1.7 (0.7–3.9); 0.2 1.0 (0.5–2.2); 0.9 1.3 (0.7–2.4); 0.3 0.9 (0.5–1.8); 0.8
APOA5 gene
Polymorphism −1131 T/C
Genotype T/C + C/C 0.9 (0.5–1.7); 0.7 0.7 (0.3–1.7); 0.4 0.9 (0.4–2); 0.9 0.8 (0.4–1.4); 0.4 1.9 (1.0–3.6); 0.05
Interaction T/C + C/C – SFA (≥12 g/d) 1.4 (0.5–3.5); 0.5 0.5 (0.1–2.2); 0.3 1.4 (0.5–3.8); 0.5 1.0 (0.4–2.5); 0.9 2.1 (0.9–5.0); 0.09
Interaction T/C + C/C – Total fat (≥83 g/d) 0.9 (0.4–2.5); 0.9 0.5 (0.1–2.5); 0.4 1.2 (0.4–3.5); 0.7 1.0 (0.4–2.4); 1.0 1.9 (0.8–4.8); 0.13
Polymorphism 56 C/G
Genotype G/G 0.97 (0.5–1.8); 0.9 0.8 (0.4–1.8); 0.6 0.6 (0.3–1.2); 0.1 0.7 (0.4–1.3); 0.2 0.7 (0.4–1.2); 0.2
Interaction G/G – SFA (≥12 g/d) 2.7 (1.3–5.6); 0.006 0.97 (0.4–2.4); 0.9 1.2 (0.6–2.6); 0.6 0.8 (0.45–1.6); 0.6 0.8 (0.4–1.6); 0.5
Interaction G/G – Total fat (≥83 g/d) 2.4 (1.2–4.9); 0.018 1.1 (0.4–2.6); 0.9 1.0 (0.5–2.3); 0.9 0.7 (0.4–1.4); 0.4 0.8 (0.4–1.5);0.5
LEPR gene
Polymorphism 1968 G/C
Genotype G/C + C/C 1.3 (0.6–2.5); 0.5 0.7 (0.3–1.8); 0.5 0.8 (0.4–1.8); 0.6 0.8 (0.4–1.4); 0.4 0.8 (0.4–1.5); 0.5
Interaction G/C + C/C – SFA (≥12 g/d) 2.2 (0.9–5.3); 0.07 0.5 (0.1–1.9); 0.3 0.9 (0.4–2.4); 0.9 1.2 (0.5–2.7); 0.6 0.7 (0.3–1.7); 0.5
Interaction G/C + C/C – Total fat (≥83 g/d) 2.5 (1.0–6.2); 0.05 0.9 (0.3–2.8); 0.8 0.8 (0.3–2.2); 0.7 1.6 (0.7–3.7); 0.3 0.6 (0.2–1.3); 0.2
Polymorphism 668 A/G
Genotype A/G + G/G 1.1 (0.6–2.1); 0.7 9.4 (2.1–41.5); 0.003 1.8 (0.8–3.9); 0.2 1.5 (0.8–2.8); 0.2 0.9 (0.5–1.7); 0.7
Interaction A/G + G/G – SFA (≥12 g/d) 2.9 (1.5–5.8); 0.002 3.8 (1.6–8.5); 0.002 2.4 (1.2–4.9); 0.02 1.9 (1.0–3.6); 0.05 1.3 (0.7–2.4); 0.4
Interaction A/G + G/G – Total fat (≥83 g/d) 3.0 (1.5–6.2); 0.002 4.1 (1.8–9.6); 0.001 1.6 (0.8–3.4); 0.2 1.6 (0.8–3.2); 0.14 1.3 (0.7–2.5); 0.4
APOA2 gene
Polymorphism −265 T/C
Genotype T/C + C/C 0.7 (0.4–1.4); 0.3 0.9 (0.4–2.4); 0.9 0.5 (0.2–1.2); 0.1 0.8 (0.4–1.5); 0.5 1.0 (0.5–1.9); 0.9
Interaction T/C + C/C – SFA (≥12 g/d) 2.2 (0.8–5.6); 0.1 1.2 (0.4–3.9); 0.7 0.4 (0.1–1.6); 0.2 1.6 (0.6–3.9); 0.3 1.4 (0.6–1.2); 0.4
Interaction T/C + C/C – Total fat (≥83 g/d) 1.3 (0.6–3.1); 0.5 0.6 (0.2–2.2); 0.5 0.3 (0.08–1.1); 0.07 0.6 (0.3–1.4); 0.3 1.4 (0.6–3.1); 0.4
  1. OR odds ratio, CI confidence interval, SFA saturated fatty acids; Reference category is genotype with major and/or minor frequency with low intake total fat and/or SFA, SFA saturated fatty acids, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol
  2. aOR adjusted by sex, age and physical activity