Fig. 4From: Apolipoprotein-J prevents angiotensin II-induced apoptosis in neonatal rat ventricular cellsSignaling pathway diagram of ApoJ action in NRVCs. 1) In control adenovirus-infected cells, AngII stimulates phosphorylation of MAPK and Akt, which enables the activation of NF-κB and NADPH oxidase and consequently induction of apoptosis in NRVCs. 2) In NRVCs, p38 MAPK, NF-κB, Akt and NADPH oxidase activated by AngII are blocked by overexpression of ApoJBack to article page