Association between the APOB XbaI and EcoRI polymorphisms and lipids in Chinese: a meta-analysis

Table 2 Overall and subgroup associations of the APOB XbaI polymorphism and lipids

Lipids	Overall or subgroups	Studies	Subjects	OR (95 %)	P _value	P_heterogenity	P_e
TC	Overall	37	5468	−0.55[−0.86,−0.23]	0.0006	<0.01	0.08
	Han	34	4812	−0.59[−0.94,−0.24]	0.001	<0.01
	Non-Han minorities	3	651	−0.25[−0.61, 0.10]	0.16	0.08
	HT	16	2708	−0.61[−1.3, 0.07]	0.08	<0.01
	CHD	3	322	0.02[−0.37, 0.42]	0.90	0.71
	CI	6	577	−0.85[−1.46,−0.24]	0.007	<0.01
	Hyperlipidemia	5	957	−0.24[−0.71, 0.22]	0.31	<0.01
	Cholelithiasis	4	456	−0.54[−0.91,−0.18]	0.004	0.11
TG	Overall	37	5425	−0.30[−0.47,−0.14]	0.0004	<0.01	0.25
	Han	34	4774	−0.32[−0.50,−0.13]	0.0009	<0.01
	Non-Han minorities	3	651	−0.19[−0.41, 0.02]	0.08	0.98
	HT	17	2851	−0.31[−0.62, 0.00]	0.05	<0.01
	CHD	3	322	−0.53[−0.93,−0.13]	0.009	0.41
	CI	6	577	−0.50[−1.02, 0.02]	0.06	0.0001
	Hyperlipidemia	5	957	−0.29[−0.62, 0.04]	0.09	0.01
	Cholelithiasis	4	456	−0.11[−0.34, 0.12]	0.36	0.86
LDL	Overall	38	5611	−0.23[−0.46,−0.00]	0.05	<0.01	0.80
	Han	35	4960	−0.23[−0.49, 0.03]	0.09	<0.01
	Non-Han minorities	3	651	−0.26[−0.47,−0.04]	0.02	0.5
	HT	17	2851	−0.21[−0.60, 0.18]	0.29	<0.01
	CHD	3	322	0.15[−0.25, 0.54]	0.47	0.6
	CI	6	577	−0.52[−1.08, 0.05]	0.07	<0.01
	Hyperlipidemia	5	957	0.15[−0.47, 0.78]	0.63	<0.01
	Cholelithiasis	4	456	−0.4[−0.64,−0.17]	0.0007	0.46
HDL	Overall	36	5337	0.17[−0.08, 0.41]	0.18	<0.01	0.86
	Han	33	4686	0.15[−0.12, 0.43]	0.27	<0.01
	Non-Han minorities	3	651	0.24[0.01, 0.47]	0.04	0.33
	HT	17	2851	0.11[−0.43, 0.64]	0.07	<0.01
	CHD	3	322	0.50[0.11, 0.90]	0.01	0.78
	CI	6	577	0.43[0.13, 0.74]	0.005	0.11
	Hyperlipidemia	4	869	0.10[−0.08, 0.27]	0.27	0.97
	Cholelithiasis	4	456	−0.10[−0.33, 0.13]	0.40	0.78

TC total cholesterol, TG triglyceride, LDL low density lipoprotein, HDL high density lipoprotein, HT healthy individuals, CHD coronary heart disease, CI cerebral infarction
P _value: the significance of the pooled estimate (95 % confidence interval)
P_{heterogeneity}: the Q statistic for heterogeneity
P_e: Egger’s statistic for publication bias
All results were calculated under the dominant genetic model (X-X- vs. X + X-/X + X+)

ISSN: 1476-511X