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Table 1 Phenotypic comparison of rats fed the CON, WD, or FOH diets for 16 weeks

From: Fish oil alleviated high-fat diet–induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study

 

CON

WD

FOH

Body weight, g

381 ± 15

478 ± 14a

461 ± 15 a

Plasma variables

   

Glucose, mmol/L

7.42 ± 0.25

7.77 ± 0.22

7.75 ± 0.26

TG, mmol/L

0.61 ± 0.06

1.16 ± 0.16 a

0.56 ± 0.04b

TCh, mmol/L

1.51 ± 0.13

2.87 ± 0.21 a

1.25 ± 0.05 b

HDL-C, mol/L

0.74 ± 0.04

0.58 ± 0.03

0.52 ± 0.02

LDL-C, mmol/L

0.57 ± 0.02

1.8 ± 0.33 a

0.29 ± 0.05 b

NEFA, μmol/L

964.16 ± 65.73

1551.12 ± 88.06 a

1284.85 ± 25.59 a b

ALT, U/L

47.32 ± 1.31

68.4 ± 1.95 a

56.82 ± 1.63 a b

AST, U/L

94.74 ± 2.2

166.98 ± 9.37 a

120.12 ± 4.67 ab

GST, U/L

80 ± 1.78

104.25 ± 4.52 a

81.67 ± 1.21 b

SOD, U/L

175.95 ± 5.23

144.36 ± 5.75 a

161.82 ± 3.13b

Liver variables

   

Weight, g

13.08 ± 1.38

22.80 ± 4.22 a

21.69 ± 1.89 a

Liver to body weight ratio, %

3.09 ± 0.22

4.79 ± 0.62 a

4.43 ± 0.31 a

TG, μmol/mg protein

0.20 ± 0.05

0.5 ± 0.07 a

0.34 ± 0.10 b

TCh, μmol/mg protein

0.4 ± 0.01

1.19 ± 0.14 a

0.43 ± 0.03 b

  1. TG: triacylglycerol, TCh: total cholesterol, HDL-C: high-density lipoprotein cholesterol, LDL-C: low-density lipoprotein cholesterol, NEFA: non-esterified fatty acid, ALT: alanine aminotransferase, AST: aspartate aminotransferase, GST: glutathione S- transferase, SOD: superoxide dismutase.
  2. Values are expressed as mean ± SD; n = 10 in each treatment group. a P < 0.05 compared with CON, b P < 0.05 compared with WD.