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Table 1 Body weight, organ weight, feed intake, and plasma lipids in control and TTP-treated micea

From: Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice

 

Diet groups

 

Control

0.3 % TTP

0.6 % TTP

0.9 % TTP

Body weightb (g)

28.7 ± 1.1

23.8 ± 1.3***

22.5 ± 0.8***

22.4 ± 1.3***

Feed intakec (g)

4.2 ± 0.3

3.3 ± 0.7*

3.1 ± 0.9**

3.2 ± 0.4*

Hepatic indexd (%)

4.6 ± 0.7

4.5 ± 0.6

5.1 ± 0.7

5.0 ± 0.8

Plasma ALT (u/L)

29.7 ± 2.6

38.9 ± 25.8

31.8 ± 8.9

32.7 ± 6.9

Plasma TAG (mmol/L)

0.63 ± 0.11

0.60 ± 0.15

0.65 ± 0.17

0.51 ± 0.15

Plasma chol (mmol/L)

2.67 ± 0.41

2.62 ± 0.41

2.74 ± 0.23

3.08 ± 0.28

Plasma PL (mmol/L)

2.75 ± 0.35

2.62 ± 0.34

2.68 ± 0.25

2.75 ± 0.27

Plasma NEFA (mmol/L)

0.16 ± 0.06

0.37 ± 0.13

0.39 ± 0.30

0.50 ± 0.20**

Plasma glucose (mmol/L)

14.8 ± 2.1

12.1 ± 1.3*

11.0 ± 2.1***

11.2 ± 1.0**

  1. Abbreviations: ALT alanine aminotransferase; NEFA non-esterified fatty acids; TTP tetradecylthiopropionic acid; TAG triacylglycerol; PL phospholipids; Chol, cholesterol
  2. aValues are means with standard deviation (n = 7–8), and values statistically different from control were determined by one-way ANOVA with Dunnett’s post hoc test (*P < 0.05, **P < 0.01, ***P < 0.001)
  3. bBody weight after two weeks of treatment
  4. cAverage feed intake per mouse per day calculated from measurements every 3 days throughout the experiment (n = 3)
  5. dHepatic index was calculated as percentage of liver weight to body weight