Role of a common variant of Fat Mass and Obesity associated (FTO) gene in obesity and coronary artery disease in subjects from Punjab, Pakistan: a case control study

Table 3 Effect of rs9939609 on biochemical traits in the study subjects

Group	Parameter	Genotype			p-value
Group	Parameter	TT	TA	AA	p-value
Controls (n = 250)	Total cholesterol (mmol/L)	4.38 ± 1.12	4.72 ± 1.36	4.67 ± 0.66	0.123
	Triglycerides (mmol/L)	2.34 ± 0.66	2.16 ± 0.75	2.73 ± 1.22	0.109
	HDLC (mmol/L)	1.80 ± 0.41	1.67 ± 0.15	1.65 ± 0.43	0.119
	LDLC (mmol/L)	2.13 ± 0.41	2.25 ± 0.48	2.26 ± 0.55	0.187
	FBG (mg/dL)	90.54 ± 6.81	90.81 ± 7.98	89.81 ± 5.41	0.019*
CAD (n = 425)	Total cholesterol (mmol/L)	5.41 ± 1.41	5.30 ± 1.36	5.38 ± 1.37	0.735
	Triglycerides (mmol/L)	2.35 ± 0.85	2.43 ± 0.81	2.41 ± 0.66	0.603
	HDLC (mmol/L)	1.15 ± 0.32	1.18 ± 0.29	1.16 ± 0.30	0.795
	LDLC (mmol/L)	2.73 ± 0.72	2.75 ± 0.73	2.71 ± 0.85	0.953
	FBG (mg/dL)	97.14 ± 6.81	98. + 1 ± 5.98	100.41 ± 6.41	0.014*
Obese (n = 295)	Total cholesterol (mmol/L)	5.50 ± 0.91	5.50 ± 0.74	5.49 ± 0.64	0.998
	Triglycerides (mmol/L)	2.51 ± 0.76	2.46 ± 0.75	2.71 ± 1.05	0.405
	HDLC (mmol/L)	1.11 ± 0.11	1.13 ± 0.11	1.07 ± 0.10	0.105
	LDLC (mmol/L)	2.96 ± 0.56	3.04 ± 0.54	2.95 ± 0.58	0.552
	FBG (mg/dL)	101.91 ± 13.52	104.21 ± 17.65	109.92 ± 16.54	0.001*

The table shows a comparison of mean biochemical parameters for three different genotypes in the study groups with strength of effect indicated by the p-value. CAD Coronary Artery Heart group, HDL-C High Density Lipoprotein cholesterol, LDL-C Low Density Lipoprotein cholesterol, FBG fasting blood glucose,*indicates any significant association

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