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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association

Fig. 1

Pitavastatin decreased CETP and SREBP-1c mRNA levels, and increased ApoA-I mRNA levels in HepG2 cells, and T0901317 abolished the decreasing effects. HepG2 cells grown to semi-confluence were treated with DMEM containing no pitavastatin or T0901317 (control), 5 μM pitavastatin alone, or 5 μM pitavastatin plus T0901317 (3 or 500 nM) for 24 h. Results were the mean ± SD of three independent experiments in duplicate or triplicate (n = 8-9). *P < 0.05 and **P < 0.01 significantly different from cells under the indicated conditions, according to ANOVA with Scheffé’s post hoc test. Footnote: Concentrations used of T0901317 were different (500nM for CETP and 3 nM for SREBP-1c) in order to show clearly significant differences in CETP and SREBP-1c expression among three groups

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Lipids in Health and Disease

ISSN: 1476-511X